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Breast Cancer: Basic and Clinical Research

Synopsis: An open access, peer reviewed electronic journal that covers all areas of breast cancer research and treatment.


Indexing: 4 major databases. Pubmed indexing for NIH-funded research.

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About this journal

ISSN: 1178-2234



Aims and scope:

Breast Cancer: Basic and Clinical Research is an international, open access, peer reviewed journal which considers manuscripts on all areas of breast cancer research and treatment. These areas include: breast cancer biology and pathogenesis, clinical interventions, and epidemiology and population genetics.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

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This journal has been awarded a SPARC Europe Seal. The Seal is an initiative of SPARC Europe (Scholarly Publishing and Academic Resources Coalition) and the Directory of Open Access Journals (DOAJ) which is awarded to journals applying a Creative Commons CC-BY copyright license and that make journal metadata accessible to DOAJ.  

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As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



 
 
 


Molecular Targets of Breast Cancer: AKTing in Concert

Authors: Alakananda Basu
Publication Date: 23 May 2008
Breast Cancer: Basic and Clinical Research 2008:2 11-16

Alakananda Basu

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, 76107.

Abstract

Despite significant advancement in the diagnosis and treatment of breast cancer, many patients succumb to this disease. The elucidation of aberrant signaling pathways that lead to breast cancer should help develop more effective therapeutic strategies. The Akt signaling pathway plays an important role in the development and progression of breast cancer. Overexpression/activation of Akt has been associated with poor prognosis and resistance to hormonal and chemotherapy. Although mutations in Akt are rare in breast cancer, the activity of Akt is regulated by hormones, growth factors, growth factor receptors, oncogenes and tumor suppressor genes that are often deregulated in breast cancer. The objective of this commentary is to discuss recent literature on how activation of Akt by various signaling pathways contributes to breast cancer and confers resistance to current therapy.

Categories: Cancer , Womens' health


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