Home| About us| Widget| login/register| For authors| For reviewers |Submit a paper
(close)

(Ctrl-click to select multiple journals)


How should we address you?

Your email address


 Yes, sign up now
 Sign up for general news too

Privacy Statement
 
 
 

Breast Cancer: Basic and Clinical Research

Synopsis: An open access, peer reviewed electronic journal that covers all areas of breast cancer research and treatment.


Indexing: 4 major databases. Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

Visibility: Most popular article read 900+ times.

RSS

NEWS

TWITTER
View factor
for journal
55240


About this journal

ISSN: 1178-2234



Aims and scope:

Breast Cancer: Basic and Clinical Research is an international, open access, peer reviewed journal which considers manuscripts on all areas of breast cancer research and treatment. These areas include: breast cancer biology and pathogenesis, clinical interventions, and epidemiology and population genetics.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

Indexing:

This journal is indexed by:

  • Google Scholar
  • CAS
  • DOAJ
  • OAIster

SPARC Europe Seal award winner:

This journal has been awarded a SPARC Europe Seal. The Seal is an initiative of SPARC Europe (Scholarly Publishing and Academic Resources Coalition) and the Directory of Open Access Journals (DOAJ) which is awarded to journals applying a Creative Commons CC-BY copyright license and that make journal metadata accessible to DOAJ.  

Amongst other important services DOAJ makes metadata OAI-compliant.  This in turn enhances the visibility of papers and allows OAI-harvesters to include the details of journal articles in their services. We encourage readers to make use of this valuable resource.  The DOAJ search page is available here.

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



 
 
 


Comparison and Identification of Estrogen-Receptor Related Gene Expression Profiles in Breast Cancer of Different Ethnic Origins

Authors: Hsiao-Wei Chen, Hsuan-Cheng Huang, Yi-Shing Lin, King-Jen Chang, Wen-Hung Kuo, Hsiao-Lin Hwa, Fon-Jou Hsieh and Hsueh-Fen Juan
Publication Date: 25 Mar 2008
Breast Cancer: Basic and Clinical Research, 2008:1 35-49

Hsiao-Wei Chen†,1,2, Hsuan-Cheng Huang†,3, Yi-Shing Lin4, King-Jen Chang5, Wen-Hung Kuo5, Hsiao-Lin Hwa6, Fon-Jou Hsieh1,6,9 and Hsueh-Fen Juan1,7,8,9

1Department of Life Science, National Taiwan University, Taipei 106, Taiwan. 2Institute of Biomedical Engineering, National Taiwan University, Taipei 106, Taiwan. 3Institute of Biomedical Informatics, National Yang-Ming University, Taipei 112, Taiwan. 4Welgene Biotech. Co., Ltd., Taipei, Taiwan. 5Department of Surgery, College of Medicine, National Taiwan University, Taipei 106, Taiwan. 6Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei 106, Taiwan. 7Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan. 8Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 106, Taiwan. 9Center for Systems Biology and Bioinformatics, National Taiwan University, Taipei 106, Taiwan.

These authors contributed equally to this work.

Abstract

The interactions between genetic variants in estrogen receptor (ER) have been identified to be associated with an increased risk of breast cancer. Available evidence indicates that genetic variance within a population plays a crucial role in the occurrence of breast cancer. Thus, the comparison and identification of ER-related gene expression profi les in breast cancer of different ethnic origins could be useful for the development of genetic variant cancer therapy. In this study, we performed microarray experiment to measure the gene expression profiles of 59 Taiwanese breast cancer patients; and through comparative bioinformatics analysis against published U.K. datasets, we revealed estrogen-receptor (ER) related gene expression between Taiwanese and British patients. In addition, SNP databases and statistical analysis were used to elucidate the SNPs associated with ER status. Our microarray results indicate that the expression pattern of the 65 genes in ER+ patients was dissimilar from that of the ER- patients. Seventeen mutually exclusive genes in ER-related breast cancer of the two populations with more than one statistically significant SNP in genotype and allele frequency were identified. These 17 genes and their related SNPs may be important in population-specific ER regulation of breast cancer. This study provides a global and feasible approach to study population-unique SNPs in breast cancer of different ethnic origins.



Post comment




No comments yet...Be the first to comment.

Bookmark this article

LINKEDIN FACEBOOK

Add to Mixx! MIXX YAHOO! BUZZ

PERMALINK DIGG


Sign up for free journal updates

How should we address you?
Your email address
 Yes, sign up now


Recently published in this journal

Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin
- 02/Sep/2009

Growth Factor Receptors and Apoptosis Regulators: Signaling Pathways, Prognosis, Chemosensitivity and Treatment Outcomes of Breast Cancer
- 17/Aug/2009

Quality of Life and Neutropenia in Patients with Early Stage Breast Cancer: A Randomized Pilot Study Comparing Additional Treatment with Mistletoe Extract to Chemotherapy Alone
- 06/Jul/2009

Effects of Celecoxib and Ly117018 Combination on Human Breast Cancer Cells in Vitro
- 07/Apr/2009

Expression of Estrogen Sulfotransferase 1E1 and Steroid Sulfatase in Breast Cancer: A Immunohistochemical Study
- 20/Mar/2009

Urine Biomarkers of Risk in the Molecular Etiology of Breast Cancer
- 06/Jan/2009

Cost-Effective Screening for Breast Cancer Worldwide: Current State and Future Directions
- 02/Jul/2008

Rethinking Breast Self-Examinations: Are We Asking the Right Questions?
- 17/Jun/2008

A Research Agenda for Appearance Changes Due to Breast Cancer Treatment
- 16/Jun/2008

Tumor Microvasculature: Endothelial Leakiness and Endothelial Pore Size Distribution in a Breast Cancer Model
- 06/Jun/2008

Circumareolar Mastopexy with Multiple Glandular Plications for Symmetry of the Contra-Lateral Breast, in Patients Undergoing Breast Reconstruction with Prosthesis. Experience on 50 Cases
- 29/May/2008

Podosomes and Invadopodia: Related structures with Common Protein Components that May Promote Breast Cancer Cellular Invasion
- 29/May/2008

Molecular Targets of Breast Cancer: AKTing in Concert
- 23/May/2008

Computer-Aided Detection of Breast Cancer – Have All Bases Been Covered?
- 23/May/2008

The Cell Surface Estrogen Receptor, G Protein- Coupled Receptor 30 (GPR30), is Markedly Down Regulated During Breast Tumorigenesis
- 17/Apr/2008

The MUC1 Cytoplasmic Tail and Tandem Repeat Domains Contribute to Mammary Oncogenesis in FVB Mice
- 17/Apr/2008

G-Protein Inwardly Rectifying Potassium Channel 1 (GIRK1) Knockdown Decreases Beta-Adrenergic, MAP Kinase and Akt Signaling in the MDA-MB-453 Breast Cancer Cell Line
- 26/Mar/2008

A Decade of Change: An Institutional Experience with Breast Surgery in 1995 and 2005
- 25/Mar/2008

Comparison and Identification of Estrogen-Receptor Related Gene Expression Profiles in Breast Cancer of Different Ethnic Origins
- 25/Mar/2008

Reversed Expression of the JAK/STAT Pathway Related Proteins Prolactin Receptor and STAT5a in Normal and Abnormal Breast Epithelial Cells
- 26/Feb/2008

The Reality in the Surveillance of Breast Cancer Survivors—Results of a Patient Survey
- 26/Feb/2008

In Search of Breast Cancer Culprits: Suspecting the Suspected and the Unsuspected
- 15/Jan/2008



Related journals...