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Breast Cancer: Basic and Clinical Research

Synopsis: An open access, peer reviewed electronic journal that covers all areas of breast cancer research and treatment.


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ISSN: 1178-2234



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Breast Cancer: Basic and Clinical Research is an international, open access, peer reviewed journal which considers manuscripts on all areas of breast cancer research and treatment. These areas include: breast cancer biology and pathogenesis, clinical interventions, and epidemiology and population genetics.

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Reversed Expression of the JAK/STAT Pathway Related Proteins Prolactin Receptor and STAT5a in Normal and Abnormal Breast Epithelial Cells

Authors: Gary L. Bratthauer, Brian L. Strauss and Ross Barner
Publication Date: 26 Feb 2008
Breast Cancer: Basic and Clinical Research, 2008:1 7-14

Gary L. Bratthauer1, Brian L. Strauss2 and Ross Barner3

1Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington. 2Quest Diagnostics Incorporated, Las Vegas NV. 3Department of Pathology, Walter Reed Army Medical Center, Washington DC.

Abstract

The JAK/STAT pathway is important for cellular metabolism. One component, STAT5a, is activated in the breast upon prolactin to prolactin receptor (PRLR) binding facilitating the transcription of genes involved in lobule development. STAT5a was previously found to be expressed in most normal breast epithelial cells but not in many in situ or invasive carcinomas except secretory carcinomas which retain STAT5a expression. This report examines the JAK/STAT pathway in the breast through the detection of PRLR and STAT5a. Fifty breast tissues, including benign secretory change, microglandular adenosis, usual and atypical hyperplasia and in situ and invasive ductal carcinoma both usual and secretory, were obtained from the fi les of the Armed Forces Institute of Pathology. Sections were immunostained with antibodies to PRLR and STAT5a. PRLR was minimally detected on the surface of a few normal breast epithelial cells whereas STAT5a was greatly expressed in over 80% of normal cell nuclei. PRLR was also minimally detected in secretory carcinomas expressing STAT5a. However, the opposite pattern was seen in breast carcinomas lacking STAT5a expression. PRLR was abundantly expressed in these cells. This reversed expression may indicate a JAK/STAT pathway disturbance that could play a role in the initiation or maintenance of an abnormal breast phenotype.

Categories: Cancer , Womens' health


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