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Clinical Medicine: Pathology

Synopsis: An open access, peer reviewed electronic journal that covers histopathology, haematology, biochemistry, virology, parasitology, infection control and medical microbiology.


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About this journal

ISSN: 1178-1181


Aims and scope:

Clinical Medicine: Pathology is an international, open access, peer reviewed journal which considers manuscripts on histopathology, haematology, biochemistry, virology, parasitology, infection control and medical microbiology.

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Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

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As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

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P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN)

Authors: Ann E. Walts, Juan Lechago, Bing Hu, MaryBeth Shwayder, Lynn Sandweiss and Shikha Bose
Publication Date: 09 Feb 2008
Clinical Medicine: Pathology 2008:1 7-13

Ann E. Walts1, Juan Lechago1*, Bing Hu1, MaryBeth Shwayder1, Lynn Sandweiss2 and Shikha Bose1

1Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA. 2Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, CA. *Deceased.

Abstract

Background: Significant variation is reported in the diagnosis of HPV-associated AIN. We previously observed that bandlike positivity for p16 in >90% of contiguous cells coupled with Ki67 positivity in >50% of lesional cells is strongly associated with high grade AIN. This study was undertaken to determine if addition of p16 and Ki67 immunostaining would reduce inter- and intraobserver variability in diagnosis and grading of AIN.

Design: H&E stained slides of 60 anal biopsies were reviewed by three pathologists and consensus diagnoses were achieved: 25 negative, 12 low (condyloma and/or AIN I) and 23 high (9 AIN II and 14 AIN III) grade lesions. The H&E stained slides were diagnosed independently by three additional (“participant”) pathologists. Several weeks later they re-examined these slides in conjunction with corresponding p16 and Ki67 immunostains.

Results: Addition of p16 and Ki67 immunostains reduced intra- and interobserver variability, improved concurrence with consensus diagnoses and reduced two-step differences in diagnosis. Negative and high grade AIN diagnoses showed the most improvement in concurrence levels.

Conclusion: Addition of p16 and Ki67 immunostains is helpful in the diagnosis and grading of AIN.

Categories: Cancer , Oncology


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