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Clinical Medicine: Pathology

Synopsis: An open access, peer reviewed electronic journal that covers histopathology, haematology, biochemistry, virology, parasitology, infection control and medical microbiology.


Indexing: 6 major databases. Pubmed indexing for NIH-funded research.

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About this journal

ISSN: 1178-1181


Aims and scope:

Clinical Medicine: Pathology is an international, open access, peer reviewed journal which considers manuscripts on histopathology, haematology, biochemistry, virology, parasitology, infection control and medical microbiology.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

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This journal is indexed by the following services:

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This journal has been awarded a SPARC Europe Seal. The Seal is an initiative of SPARC Europe (Scholarly Publishing and Academic Resources Coalition) and the Directory of Open Access Journals (DOAJ) which is awarded to journals applying a Creative Commons CC-BY copyright license and that make journal metadata accessible to DOAJ.  

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National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



 
 
 


Progesterone and Estrogen Receptors in Neurofibromas of Patients with NF1

Authors: Mauro Geller, Spyros G.E. Mezitis, Fabio Pereira Nunes, Marcia G. Ribeiro, Alexandra Prufer de Q.C. Araújo, Marcelo D. Bronstein, Rodrigo Siqueira-Batista, Andréia Patrícia Gomes, Lisa Oliveira and Karin Soares Gonçalves Cunha
Publication Date: 15 Sep 2008
Clinical Medicine: Pathology 2008:1 93-97

Mauro Geller1,2, Spyros G.E. Mezitis3, Fabio Pereira Nunes4, Marcia G. Ribeiro2, Alexandra Prufer de Q.C. Araújo2, Marcello D. Bronstein5, Rodrigo Siqueira-Batista1, Andréia Patrícia Gomes1, Lisa Oliveira6 and Karin Soares Gonçalves Cunha1

1Teresópolis Medical School (UNIFESO)—Teresópolis, Rio de Janeiro, Brazil. 2Federal University of Rio de Janeiro—Rio de Janeiro, Rio de Janeiro, Brazil. 3New York-Presbyterian Hospital/ Weill-Cornell Medical Center and Lenox Hill Hospital—New York, NY, U.S.A. 4Massachusetts General Hospital, Harvard University, Charlestown, MA, U.S.A. 5Hospital das Clínicas (USP)—São Paulo, São Paulo, Brazil. 6Universidade do Grande Rio—Rio de Janeiro, Rio de Janeiro, Brazil.

Abstract

Neurofibromatosis type 1 (NF1) or von Recklinghausen disease is a genetic disorder affecting the growth of cells in nervous system. One of the most remarkable characteristics of this disease is the development of benign tumors of the nervous system (neurofibromas).

The purpose of this study was to test tissue samples taken from neurofibromas and plexiform neurofibromas of NF1 patients for the presence of estrogen and progesterone receptors. We used previously collected samples from patients registered in the database of the Centro Nacional de Neurofibromatose (CNNF-Brazil). Samples from twenty-five patients in the database presenting plexiform neurofibromas (N1 group) and 25 samples from the same database from patients presenting neurofibromas (N2 group) were tested.

We observed positive staining for progesterone receptors in 13 of the neurofibroma samples and 19 of the plexiform neurofibroma samples. Among the neurofibroma samples, we observed one sample with positive estrogen receptor staining, but none of the plexiform neurofibroma samples showed positive staining. We suggest further studies to investigate in greater depth possible hormonal influences on the development and growth of neurofibromas and plexiform neurofibromas in NF1.




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