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Clinical Medicine: Ear, Nose and Throat

Synopsis: An open access, peer reviewed electronic journal that covers diagnosis, management and prevention of ear, nose and throat disorders.


Indexing: Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

Visibility: Most popular article read 400+ times.

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About this journal

Clinical Medicine: Ear, Nose and Throat

ISSN: 1178-1211

Aims and scope:

Clinical Medicine: Ear, Nose and Throat is an international, open access, peer reviewed journal which considers manuscripts on all aspects of the diagnosis, management and prevention of disorders of the ear, nose and throat, in addition to related genetic, pathophysiological and epidemiological topics.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 

 
 
 


Biomarkers for Cancers of the Head and Neck

Authors: Viviana P. Lutzky, Denis J. Moss, David Chin, William B. Coman, Peter G. Parsons and Glen M. Boyle
Publication Date: 12 Sep 2008
Clinical Medicine: Ear, Nose and Throat 2008:1 5-15

Viviana P. Lutzky1, Denis J. Moss1, David Chin2, William B. Coman3, Peter G. Parsons2 and Glen M. Boyle2

1Division of Immunology and Infectious Diseases and 2Division of Cancer and Cell Biology, Queensland Institute of Medical Research, Herston, Brisbane, Queensland, Australia. 3Head and Neck Unit, Princess Alexandra Hospital, Woollongabba, Brisbane, Queensland, Australia.

Abstract

Head and neck cancer is a broad term used to describe malignancies that arise in the nasal and oral cavities, pharynx and larynx, as well as the paranasal sinuses. Head and neck squamous cell carcinoma (HNSCC) affects the squamous epithelium of the oral cavity, tongue and oropharynx, excluding the nasopharynx. Recent advances in molecular technology, including gene expression and proteomic profiling appear to offer the potential for the development of specific biomarkers including diagnostic tools which may act as an aid to guide therapy for this malignancy. The other human head and neck cancer included in this review, nasopharyngeal carcinoma (NPC) is a malignancy derived from the undifferentiated epithelium of the nasopharyngeal cavity, and is considered here as a separate entity because its strong association with Epstein-Barr virus (EBV) presents the opportunity for the development of virus related and unrelated biomarkers. In particular, IgA antibodies to EBV and high levels of EBV DNA in serum samples of NPC patients have been recorded. This review aims to summarize some current and also potential new biomarkers that could be used for screening, diagnosis, monitoring and prognostic prediction for cancers of the head and neck, including NPC and HNSCC.

Categories: Cancer , Biomarkers


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