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Clinical Medicine: Ear, Nose and Throat

Synopsis: An open access, peer reviewed electronic journal that covers diagnosis, management and prevention of ear, nose and throat disorders.


Indexing: Indexed by Google Scholar.  Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

Visibility: Most popular article read 400+ times.

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12390


About this journal

ISSN: 1178-1211


Aims and scope:

Clinical Medicine: Ear, Nose and Throat is an international, open access, peer reviewed journal which considers manuscripts on all aspects of the diagnosis, management and prevention of disorders of the ear, nose and throat, in addition to related genetic, pathophysiological and epidemiological topics.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

Indexing:

This journal is indexed by:

  • Google Scholar

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



 
 
 


Molecular Signaling in Retinoic Acid-Induced Inner Ear Teratogenesis

Authors: Frank Garritano and Dorothy A. Frenz
Publication Date: 14 Nov 2008
Clinical Medicine: Ear, Nose and Throat 2008:1 17-27

Frank Garritano1 and Dorothy A. Frenz1,2

1Departments of Otorhinolaryngology Head and Neck Surgery and 2Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461.

Abstract

Retinoic acid is an indispensable regulator of inner ear development.  However, in either excess or deficiency, retinoic acid acts as a potent teratogen.  Pathological effects produced in the inner ear by aberrant retinoic acid conditions lead to impaired functionality. This article will provide an overview of critical components of the retinoic acid signaling pathway, and demonstrate how changes in retinoid signaling affect otic development, with particular emphasis on the inner ear.  The downstream targets of retinoic acid signaling and the implications of their misexpression to otic morphogenesis are discussed.



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