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Clinical Medicine: Endocrinology and Diabetes

Synopsis: An open access, peer reviewed electronic journal that covers diabetes and endocrine disorders.


Indexing: 4 major databases. Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

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About this journal

Clinical Medicine: Endocrinology and Diabetes

ISSN: 1178-1173

Aims and scope:

Clinical Medicine: Endocrinology and Diabetes is an international, open access, peer reviewed journal which considers manuscripts on diabetes and all other disorders of the endocrine system, in addition to related genetic, pathophysiological and epidemiological topics.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

Indexing:

This journal is indexed by:

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  • Scopus
  • EMBase

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 

 
 
 


HbA1c is an Independent Determinant of Renal Vascular Resistance Estimated by Doppler Sonography in Non-Diabetic Hypertensive Patients

Authors: Ken-ichi Miyoshi, Takafumi Okura, Tomoaki Nagao, Masanori Jotoku, Daijiro Enomoto, Jun Irita, Mie Kurata and Jitsuo Higaki
Publication Date: 24 Nov 2008
Clinical Medicine: Endocrinology and Diabetes 2008:1 21-26

Ken-ichi Miyoshi, Takafumi Okura, Tomoaki Nagao, Masanori Jotoku, Daijiro Enomoto, Jun Irita, Mie Kurata and Jitsuo Higaki

Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine.

Abstract

Background:  Diabetic nephropathy is a progressive disease that leads to renal failure and end stage renal disease. A frequent and early manifestation of diabetic nephropathy is hyaline arteriolosclerosis. The noninvasive method for estimating the severity of arteriolosclerosis is measurement of the renal resistive index (RI). In this study, we determined whether or not normal blood glucose control, classified as an HbA1c  5.8%, was a sufficiently low level to prevent arteriolosclerosis in patients with essential hypertension.

Methods: The study subjects were 93 patients with essential hypertension with HbA1c levels 5.8%. Patients with a history of medication for diabetes mellitus were excluded. Blood flow velocity of the renal interlobar arteries was assessed by a Doppler ultrasonography and the RI calculated.

Results:  RI correlated positively with age, body mass index, pulse pressure, pulse rate and HbA1c, and negatively with diastolic blood pressure. A multivariate analysis identified age, pulse pressure and HbA1c as significant independent determinants of RI. Our data show that RI correlates with HbA1c independent of other variables, even in normoglycemic patients with HbA1c levels 5.8%.

Conclusions:  The results of this cross-sectional study suggest that blood glucose levels should be kept as low as possible in order to prevent arteriolosclerosis in the kidney in hypertensive patients.

Categories: Endocrine disorders


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