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Clinical Medicine: Endocrinology and Diabetes

Synopsis: An open access, peer reviewed electronic journal that covers diabetes and endocrine disorders.


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About this journal

ISSN: 1178-1173


Aims and scope:

Clinical Medicine: Endocrinology and Diabetes is an international, open access, peer reviewed journal which considers manuscripts on diabetes and all other disorders of the endocrine system, in addition to related genetic, pathophysiological and epidemiological topics.

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Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

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Diabetes Mellitus as Dysfunction of Interactions Among all Organs: “Ominous Orchestra of Organs”

Authors: Hiroyuki Koshiyama, Yoshihiro Ogawa, Kiyoshi Tanaka, and Issei Tanaka
Publication Date: 01 Mar 2008
Clinical Medicine: Endocrinology and Diabetes 2008:1 1-6

Hiroyuki Koshiyama1,2, Yoshihiro Ogawa3,4, Kiyoshi Tanaka2,5, and Issei Tanaka6

1Center for Diabetes and Endocrinology, The Tazuke Kofukai Foundation Medical Research Institute Kitano Hospital, Osaka, Japan. 2Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 3Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. 4Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstitution of Tooth and Bone, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. 5Department of Food and Nutrition, Kyoto Women’s University, Kyoto, Japan. 6Keihanna Hospital, Hirakata, Japan.

Abstract

Epidemiological evidence has established a link among hyperlipidemia, visceral obesity, osteoporosis, and cardiovascular diseases. We have recently proposed a hypothesis that the associations of those disorders are based on interactions of the three organs, i.e. the bone, adipose, and vascular tissues, possibly through multiple actions of several humoral factors and/or transcription factors. We call this unified hypothesis ‘osteo-lipo-vascular interactions’, which may be explained by the common origin of the cells in each organ, such as mesenchymal stem cells or macrophages. Several groups proposed similar hypotheses. On the other hand, there have been accumulating evidences which indicate that there exist hitherto unknown various interactions between many organs, such as hypothalamus-liver, fat-liver, liver-muscle, intestine-pancreas, kidney-heart and so on. Therefore, it seems insufficient to consider only the interactions among several organs, and the standpoint of considering interactions among all organs may be warranted, especially in order to understand the pathogenesis of metabolic syndrome, insulin resistance and type 2 diabetes. We here propose a hypothesis that the abnormal interactions of all organs (“Ominous Orchestra of Organs”) underlies the pathogenesis of type 2 diabetes. It is to be elucidated which of the “players” or the “conductor” may be mainly responsible for disharmony of the orchestra.

Categories: Endocrine disorders


Post comment




Posted by
Hiro Koshiyama
03:35,February 11, 2009

Dear Dr Thomas Hach, Thank you very much for your kind comments. I know that Dr DeFronzo made a lecture including "ominous octet" at ADA 08. Our paper was originally inspired by his lecture at EASD 07.

Posted by
Thomas Hach
06:59,July 08, 2008

Excellent perspective on the multifactorial pathophysiological aspects in diabetes. Please compare Dr. DeFronzo's Banting lecture at ADA, where he proposed the "ominous octet" for diabetes pathophysiology.


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