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Clinical Medicine: Endocrinology and Diabetes

Synopsis: An open access, peer reviewed electronic journal that covers diabetes and endocrine disorders.


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About this journal

ISSN: 1178-1173



Aims and scope:

Clinical Medicine: Endocrinology and Diabetes is an international, open access, peer reviewed journal which considers manuscripts on diabetes and all other disorders of the endocrine system, in addition to related genetic, pathophysiological and epidemiological topics.

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Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

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Abnormality of Serum Lipids are Independently Associated with Increased Serum Calcium Level in the Adult Newfoundland Population

Authors: Aaron Kennedy, Sudesh Vasdev, Edward Randell, Ya-Gang Xie, Kristian Green, Hongwei Zhang and Guang Sun
Publication Date: 24 Jul 2009
Clinical Medicine: Endocrinology and Diabetes 2009:2 15-23

Aaron Kennedy1, Sudesh Vasdev2, Edward Randell3, Ya-Gang Xie1,3, Kristian Green1, Hongwei Zhang1 and Guang Sun1

1Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada. 2Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada. 3Division of Laboratory Medicine, Memorial University of Newfoundland, The General Hospital, Health Sciences Centre Site, St. John’s, Newfoundland, Canada.

Abstract

Some epidemiological evidence shows a link between abnormality of lipid profiles and variations in serum calcium. However, it is unknown whether this association resulted from confounding factors. The present study was designed to investigate the relationship between serum lipids and calcium. Serum calcium was corrected for albumin. Major confounding factors including age, gender, medications, menopause, parathyroid hormone (PTH) and 25-OH-vitamin D status were controlled in analyses. A total of 1907 adult subjects from the province of Newfoundland and Labrador (NL), Canada participated in the study. Significant positive correlations were detected between serum total cholesterol and high density lipoprotein-cholesterol (HDL-c) with variations of serum Ca++ in both genders (p < 0.05–0.0001). Significant positive correlations were additionally detected between triglycerides (TG) and low density lipoprotein-cholesterol (LDL-c) with Ca++ in women only (p < 0.0001) in partial correlation analyses. Similar significant results were detected in both females and males not taking any medication. Analyses were performed based on menopausal status as well. Significant correlations were seen in both pre- and post-menopausal women but higher correlation coefficients were observed in pre-menopausal women as compared to post-menopausal women. Subjects with low calcium levels had the lowest concentration of total cholesterol, TG, HDL-c and LDL-c, while subjects with high calcium levels had the highest concentration of all four markers in women. The significant associations between cholesterol, TG and LDL-c and serum Ca++ remained after calcium was adjusted for 25-OH-vitamin D and PTH. Our results indicate that the abnormality of serum lipid profiles are significantly correlated with altered serum Ca++ levels independent of age, obesity status, medication, phosphorus, magnesium, 25-OH-vitamin D and PTH.

Categories: Endocrine disorders


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