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Clinical Medicine: Reproductive Health

Synopsis: An open access, peer reviewed electronic journal that covers human reproductive health.


Indexing: 2 major databases. Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

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About this journal

ISSN: 1178-6299



Aims and scope:

Clinical Medicine: Reproductive Health is a peer-reviewed, open access journal that encompasses all aspects of human reproductive health. It covers both male and female issues, from the physical to the psychological and the social. Submissions on sex, contraception, pregnancy, childbirth, and related topics such as social and emotional impacts are welcome.

Clinical subjects include sterility, infertility and assisted reproduction, pregnancy problems, PPD, infections and disease, surgery, diagnosis, menopause, HRT, pelvic floor problems, reproductive cancers and environmental impacts on reproduction, although this list is by no means exhaustive.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

Indexing:

This journal is indexed by:

  • CAS
  • OAIster

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



 
 
 


Endometrial Thickness- a Practical Prospective Marker for the Risk of Surgical Intervention after RU486 Induced Abortion

Authors: Zeev Blumenfeld, William Abdallah, Dalia Kaplan and Ori Nevo
Publication Date: 17 Nov 2008
Clinical Medicine: Reproductive Health 2008:2 25-30

Zeev Blumenfeld, William Abdallah, Dalia Kaplan and Ori Nevo

Reproductive Endocrinology, Dpt. of Ob/Gyn, RAMBAM Health Care Campus and Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa, 31096, Israel.

Abstract

Background: Medical termination of pregnancy [TOP] during the early first trimester is commonly used. However, treatment failure which warrants surgical intervention occurs in small proportion of patients. Our objective was to examine the effectiveness and predictive value of sonographic measurement of endometrial thickness during a follow up visit after medical abortion as an accurate predictor of the necessity of curettage for completion of pregnancy termination.

Methods: Women who opted for medical TOP where treated by single dose of RU486 followed by a single dose of misoprostol. Endometrial thickness was evaluated by transvaginal U.S. at 14 days after misoprostol tretament. The data was collected prospectively for this cohort study which includes all the women undergoing medical abortion in the first seven weeks of gestation.

Results: In 34.7% of the patients the endometrial width was 11 mm on the follow-up visit. Surgical intervention was performed in 18% of these patients, for a failure rate of the medical termination of pregnancy [TOP] of 6.25%, as com- pared with no failure rate in those with endometrium 11 mm, P  0.001. In the patients where the endometrium was 11–12 mm on follow-up, the failure rate was 5%, and if  12 mm the failure was 5.9%. In cases where the endometrium was 12–13 mm the failure rate was 27.3%, and if 13 mm the failure was 18.9%. When the endometrium was 13–14 mm the failure rate was 10%, and when 14 mm the failure was 23.7%. Half of the 18 patients who had undergone dilatation and curettage [D&C] for completion of the TOP, had endometrium 14 mm, one to two weeks after the medical abortion.

Conclusion: Measurement of endometrial width after medical TOP is beneficial in segregating patient to low or high risk for surgical treatment of retained product of conception [POC]. Using a cutoff of 11 mm during the follow-up visit after medical TOP, 18% of the patients may need dilatation and curettage to complete the pregnancy termination, and if it is 14 mm, half of them may need surgical intervention. There is no difference between 11 and 14 mm regarding the risk of surgical intervention after medical TOP.

Author interview

Read an interview with Dr Zeev Blumenfeld here.

 



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