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Ontologies for Bioinformatics

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1667 Article Views

Publication Date: 12 Mar 2008

Journal: Bioinformatics and Biology Insights 2008:2 187-200

BBI
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95,684 Article Views

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Abstract Nadine Schuurman and Agnieszka Leszczynski

Department of Geography, Simon Fraser University RCB 7123, 8888 University Drive, Burnaby, British Columbia, Canada, V5A 1S6.

Abstract

The past twenty years have witnessed an explosion of biological data in diverse database formats governed by heterogeneous infrastructures. Not only are semantics (attribute terms) different in meaning across databases, but their organization varies widely. Ontologies are a concept imported from computing science to describe different conceptual frameworks that guide the collection, organization and publication of biological data. An ontology is similar to a paradigm but has very strict implications for formatting and meaning in a computational context. The use of ontologies is a means of communicating and resolving semantic and organizational differences between biological databases in order to enhance their integration. The purpose of interoperability (or sharing between divergent storage and semantic protocols) is to allow scientists from around the world to share and communicate with each other. This paper describes the rapid accumulation of biological data, its various organizational structures, and the role that ontologies play in interoperability.


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