Perspectives in Medicinal Chemistry

Applications of Second-Harmonic Generation Imaging Microscopy in Ovarian and Breast Cancer
Karissa Tilbury and Paul J. Campagnola
Perspectives in Medicinal Chemistry 2015:7 21-32
Perspective | Published on 16 Apr 2015

Selective Mycobacterium tuberculosis Shikimate Kinase Inhibitors as Potential Antibacterials
Sara Gordon, Johayra Simithy, Douglas C. Goodwin and Angela I. Calderón
Perspectives in Medicinal Chemistry 2015:7 9-20
Review | Published on 15 Mar 2015

New Approaches to Treating Alzheimer’s Disease
Hailin Zheng, Mati Fridkin and Moussa Youdim
Perspectives in Medicinal Chemistry 2015:7 1-8
Perspective | Published on 09 Feb 2015

Antimicrobial Peptides and Their Analogs: Searching for New Potential Therapeutics
Krystyna Midura-Nowaczek and Agnieszka Markowska
Perspectives in Medicinal Chemistry 2014:6 73-80
Perspective | Published on 12 Oct 2014

Multiple Sclerosis: Overview of Disease-Modifying Agents
Alessandro Finkelsztejn
Perspectives in Medicinal Chemistry 2014:6 65-72
Perspective | Published on 05 Oct 2014

Antibiotics and Bacterial Resistance in the 21st Century
Richard J. Fair and Yitzhak Tor
Perspectives in Medicinal Chemistry 2014:6 25-64
Review | Published on 28 Aug 2014

Pathways for Small Molecule Delivery to the Central Nervous System Across the Blood-Brain Barrier
John L. Mikitsh and Ann-Marie Chacko
Perspectives in Medicinal Chemistry 2014:6 11-24
Review | Published on 16 Jun 2014

Corrigendum for “Stereocomplexes Formed From Select Oligomers of Polymer D-lactic Acid (PDLA) and L-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers—Applications of the Warburg Effect”
Joel S. Goldberg
Perspectives in Medicinal Chemistry 2014:6 9
Corrigendum | Published on 25 May 2014

Revisiting the Monoamine Hypothesis of Depression: A New Perspective
Joel S. Goldberg, Clifton E. Bell Jr. and David A. Pollard
Perspectives in Medicinal Chemistry 2014:6 1-8
Perspective | Published on 03 Apr 2014

Low Molecular Weight Opioid Peptide Esters Could be Developed as a New Class of Analgesics
Joel S. Goldberg
Perspectives in Medicinal Chemistry 2011:5 19-26
Perspective | Published on 25 Jul 2011

Choroidal Proteins Involved in Cerebrospinal Fluid Production may be Potential Drug Targets for Alzheimer’s Disease Therapy
Peter Wostyn, Kurt Audenaert and Peter Paul De Deyn
Perspectives in Medicinal Chemistry 2011:5 11-17
Perspective | Published on 23 Feb 2011

Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers—Applications of the Warburg Effect
Joel S. Goldberg
Perspectives in Medicinal Chemistry 2011:5 1-10
Perspective | Published on 15 Feb 2011

Selected Gamma Aminobutyric Acid (GABA) Esters may Provide Analgesia for Some Central Pain Conditions
Joel S. Goldberg
Perspectives in Medicinal Chemistry 2010:4 23-31
Review | Published on 03 Aug 2010

Fentanyl Buccal Tablet for the Treatment of Breakthrough Pain: Pharmacokinetics of Buccal Mucosa Delivery and Clinical Efficacy
Mona Darwish, Ehab Hamed and John Messina
Perspectives in Medicinal Chemistry 2010:4 11-21
Review | Published on 04 Jun 2010

Stereochemical Basis for a Unified Structure Activity Theory of Aromatic and Heterocyclic Rings in Selected Opioids and Opioid Peptides
Joel S. Goldberg
Perspectives in Medicinal Chemistry 2010:4 1-10
Hypothesis | Published on 18 Feb 2010

Chaperone Therapy for Neuronopathic Lysosomal Diseases: Competitive Inhibitors as Chemical Chaperones for Enhancement of Mutant Enzyme Activities
Yoshiyuki Suzuki, Seiichiro Ogawa and Yasubumi Sakakibara
Perspectives in Medicinal Medicine 2009:3 7-19
Review | Published on 26 May 2009

Aminoglycosides: Molecular Insights on the Recognition of RNA and Aminoglycoside Mimics
Maruthi Chittapragada, Sarah Roberts and Young Wan Ham
Perspectives in Medicinal Chemistry 2009:3 21-37
Perspective | Published on 28 Apr 2009 | Highly accessed (previous month)

Perspectives on Using Physcomitrella  Patens as an Alternative Production Platform for Thapsigargin and Other Terpenoid Drug Candidates
Henrik Toft Simonsen, Damian Paul Drew and Christina Lunde
Perspectives in Medicinal Chemistry 2009:3 1-6
Published on 04 Mar 2009

Bioactive and Structural Metabolites of Pseudomonas and Burkholderia Species Causal Agents of Cultivated Mushrooms Diseases
Anna Andolfi, Alessio Cimmino, Pietro Lo Cantore, Nicola Sante Iacobellis and Antonio Evidente
Perspectives in Medicinal Chemistry 2008:2 81-112
Published on 09 May 2008

The Role of Integrins in Cancer and the Development of Anti-Integrin Therapeutic Agents for Cancer Therapy
Xinjie Lu, Dong Lu, Mike Scully and Vijay Kakkar
Perspectives in Medicinal Chemistry 2008:2 57-73
Published on 10 Apr 2008

Drug Targeting of α-Synuclein Oligomerization in Synucleinopathies
Tiago Fleming Outeiro and Aleksey Kazantsev
Perspectives in Medicinal Chemistry 2008:2 41-49
Published on 10 Apr 2008

Lunasin: A Novel Cancer Preventive Seed Peptide
Blanca Hernández-Ledesma and Ben O. de Lumen
Perspectives in Medicinal Chemistry 2008:2 75-80
Published on 25 Mar 2008

Effects of FK506 on Ca2+ Release Channels (Review)
Terutaka Ozawa
Perspectives in Medicinal Chemistry 2008:2 51-55
Published on 18 Mar 2008

Small Family with Key Contacts: Par14 and Par17 Parvulin Proteins, Relatives of Pin1, Now Emerge in Biomedical Research
Jonathan W Mueller and Peter Bayer
Perspectives in Medicinal Chemistry 2008:2 11-20
Published on 07 Mar 2008

Modifications of Antiepileptic Drugs for Improved Tolerability and Efficacy
Cecilie Johannessen Landmark and Svein I. Johannessen
Perspectives in Medicinal Chemistry 2008:2 21-39
Published on 14 Feb 2008

Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists Toward Downsizing
Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura and Nobutaka Fujii
Perspectives in Medicinal Chemistry 2008:2 1-9
Published on 10 Feb 2008

The Role of Glucose Metabolism and Glucose-Associated Signalling in Cancer
Rainer Wittig and Johannes F. Coy
Perspectives in Medicinal Chemistry 2007:1 64-82
Published on 18 Jan 2008

Chemical Chaperone and Inhibitor Discovery: Potential Treatments for Protein Conformational Diseases
Jian-Hua Zhao, Hsuan-Liang Liu, Hsin-Yi Lin, Chih-Hung Huang, Hsu-Wei Fang, Shiao-Shing Chen, Yih Ho, Wei-Bor Tsai and Wen-Yih Chen
Perspectives in Medicinal Chemistry 2007:1 39-48
Published on 11 Dec 2007

Derivatives of 5-Aminolevulinic Acid for Photodynamic Therapy
Ryan F. Donnelly, Paul A. McCarron and A. David Woolfson
Perspectives in Medicinal Chemistry 2007:1 49-63
Published on 11 Dec 2007

The pKa Distribution of Drugs: Application to Drug Discovery
David T. Manallack
Perspectives in Medicinal Chemistry 2007:1 25-38
Published on 17 Sep 2007

FTY720 Story. Its Discovery and the Following Accelerated Development of Sphingosine 1-Phosphate Receptor Agonists as Immunomodulators Based on Reverse Pharmacology
Kunitomo Adachi and Kenji Chiba
Perspectives in Medicinal Chemistry 2007:1 11-23
Published on 06 Sep 2007

Lead Optimization in Discovery Drug Metabolism and Pharmacokinetics/Case study: The Hepatitis C Virus (HCV) Protease Inhibitor SCH 503034
K.-C. Cheng, Walter A. Korfmacher, Ronald E. White and F. George Njoroge
Perspectives in Medicinal Chemistry 2007:1 1-9
Published on 26 Jun 2007