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Perspectives in Medicinal Chemistry

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The Role of Integrins in Cancer and the Development of Anti-Integrin Therapeutic Agents for Cancer Therapy

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Publication Date: 10 Apr 2008

Journal: Perspectives in Medicinal Chemistry

Citation: Perspectives in Medicinal Chemistry 2008:2 57-73

Abstract

Integrins have been reported to mediate cell survival, proliferation, differentiation, and migration programs. For this reason, the past few years have seen an increased interest in the implications of integrin receptors in cancer biology and tumor cell aggression. This review considers the potential role of integrins in cancer and also addresses why integrins are present attractive targets for drug design. It discusses of the several properties of the integrin-based chemotherapeutic agents currently under consideration clinically and provides an insight into cancer drug development using integrin as a target.


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What Your Colleagues Say About Perspectives in Medicinal Chemistry
My experience publishing in Perspectives in Medicinal Chemistry was very positive.  The submission process was very quick and easy.  I was extremely impressed by the efficiency of the editorial staff and reviewers.
Dr Peter Wostyn (PC Sint Amandus, Beernem, Belgium)
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