Close
Help
Need Help?



CD4 Count and Anti Retroviral Therapy for HIV Positive Patients with Cancer in Nigeria - A Pilot Study

Submit a Paper


Libertas Analytics


2026 Article Views

Publication Date: 07 Jul 2010

Type: Original Research

Journal: Clinical Medicine Insights: Oncology

Citation: Clinical Medicine Insights: Oncology 2010:4 61-66

doi: 10.4137/CMO.S5028

CMIonc journal

443,111 Article Views

8,154,219 Libertas Article Views

More Statistics

Abstract

Background: Highly Active Anti Retroviral Treatment (HAART) improves the outcome of HIV positive patients treated for cancer. In our center HAART is only commenced in HIV positive patients with malignancy if the CD4 T lymphocyte count is less than 200 cells/ul. Presently, the outcome of treatment in these patients is poor.

Objective: To evaluate the influence of CD4 T- cell count and HAART on treatment outcome of HIV positive patients with cancer managed at the oncology service of The University College Hospital, Ibadan- South West Nigeria.

Patients and methods: Twenty two adult HIV positive patients with malignancies who presented for treatment at our hospital from 2007 to 2009 were closely monitored by the investigators. Relevant clinical data collected included age, sex, HIV status, type of malignancy, CD4 counts, history of ART, ECOG performance status, prescribed oncology treatment with regularity of treatment and to follow up conditions.

Results: Twenty two patients aged between 26 and 67 years were evaluated. The performance status of all patients was at least ECOG 2. Three ART naive patients with initial CD4 counts 450 cells/ul and above were able to complete oncology treatment without HAART with good malignant disease control. Five other patients on HAART before the diagnosis of malignancy with CD4 counts 350 cells/ul and above were also able to complete their treatments on schedule with good outcome. Eight HAART naive patients with initial CD4 counts less than 370 cells/ul had inconsistent treatments with poor outcome.

Conclusion: Based on these observations, we propose that HAART should be commenced on all HIV positive patients diagnosed with malignancy with an initial CD4 count less than 450 cells/ul in our environment. Further studies in low resource settings with appropriate sample sizes are however needed to validate these findings.


Downloads

PDF  (459.76 KB PDF format)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)

XML

PMC HTML


Sharing

Our Service Promise

  • Prompt Processing (Less Than 3 Weeks)
  • Fair & Comprehensive Peer Review
  • Professional Author Service
  • Leading Editors in Chief
  • Extensive Indexing
  • High Readership & Impact
  • What Your Colleagues Say

Quick Links

Follow Us We make it easy to find new research papers.
Email AlertsRSS Feeds
FacebookGoogle+Twitter
PinterestTumblrYouTube

SUBJECT HUBS
Our Testimonials
Publishing in Air, Soil and Water and Water Research was the best experience I have had so far in an academic context.  The review process was fair, quick and efficient.  I congratulate the team at Libertas Academica for a very well managed journal.
Magnus Karlsson (IVL Swedish Environmental Research Institute, Stockholm, Sweden) What Your Colleagues Say