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Nutrition and Metabolic Insights

Synopsis: An open access, peer reviewed electronic journal that covers nutrition and metabolism.


Indexing: Indexed by CAS. Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

Visibility: Most popular article read 500+ times.

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12079


About this journal

ISSN: 1178-6388


Aims and scope:

Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focused on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels.

Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

Indexing:

This journal is indexed by:

  • CAS

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



Editor in Chief's call for papers
 
 
 


Cathepsin Y Expression is Up-Regulated in Liver and Spleen of the Rats Growing Under a Low Protein Diet

Authors: Eri Nakazono, Takayoshi Yamaguchi, Keiko Yamafuji and Hiroko Tsuda
Publication Date: 04 May 2009
Nutrition and Metabolic Insights 2009:2 17-25

Eri Nakazono, Takayoshi Yamaguchi, Keiko Yamafuji and Hiroko Tsuda

Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University.

Abstract

Background/Aims: We have previously isolated a novel lysosomal cysteine protease, cathepsin Y, which produces a kinin-potenciating octapeptide from rat plasma. The present study aimed to elucidate the influence of protein-restriction on cathepsin Y mRNA expression in tissues of growing rat.

Methods:  Weaning rats were fed either 20% casein (normal-protein, NP) or 5% casein (low-protein, LP) diet for 12 weeks, from post-weaning period to maturity. Cathepsin Y mRNA expression in tissues was examined using RT-PCR and compared with that of cathepsin L, a general marker of muscle atrophy.

Results:  Body, liver and spleen weights and diet intake of LP were significantly lower than those of NP. Cathepsin Y expression in LP was increased in liver (3.70 fold vs. NP) and spleen (1.28 fold) at early periods of protein-restriction, whereas that of cathepsin L was increased in liver and pectoral muscle through all intake periods. However, significant differences were detected in neither cathepsin Y expression in pectoral muscle nor cathepsin L expression in spleen throughout intake periods.

Conclusions:  A significant up-regulation of cathepsin Y was observed in spleen and liver, suggesting that it may associate with immunodepression in rats under protein-malnutrition during the early post-weaning period.



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