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Nutrition and Metabolic Insights

Synopsis: An open access, peer reviewed electronic journal that covers nutrition and metabolism.


Indexing: Indexed by CAS. Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

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About this journal

ISSN: 1178-6388


Aims and scope:

Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focused on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels.

Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

Indexing:

This journal is indexed by:

  • CAS

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



Editor in Chief's call for papers
 
 
 


Effect of Dietary Induced Metabolic Acidosis on Bone Mineral Acquisition in 2–8 Month Old Lambs

Authors: E.S. Hackett, J.M. MacLeay, J.D. Olson, S.L. Bouzis, Steve Jackinsky and A.S. Turner
Publication Date: 10 Dec 2008
Nutition and Metabolic Insights 2009:2 1-9

E.S. Hackett1, J.M. MacLeay1, J.D. Olson2, S.L. Bouzis1, Steve Jackinsky3 and A.S. Turner1

1Small Ruminant Comparative Orthopaedic Laboratory, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, U.S.A. 2Independent Consultant, Fort Collins, CO. 3Orthopaedic Bioengineering Research Laboratory, College of Engineering, Colorado State University, Fort Collins, Colorado 80523, U.S.A.

Abstract

Dietary induced metabolic acidosis (MA) results in a negative calcium balance in normal animals. In order to maintain acid-base homeostasis the body’s primary base buffer source calcium is mobilized from bone. This study examined the impact of dietary induced MA on bone in an adolescent ovine model. We hypothesized that a MA diet would reduce bone mineral density (BMD) in growing sheep. Twelve 2 month old lambs of mixed sex were divided into 2 groups. The MA group consumed a ration that was relatively acidogenic compared to the control diet (CD) for 6 months. DXA was performed on days 0 and 180. Arterial blood samples were evaluated on days 0, 30, 120, 150 and 180 for pH, pCO2, pO2, HCT, Na, K, ionized Ca, HCO3, TCO2, base excess (BE), and O2 saturation. Histomorphometry of the femoral diaphysis was performed from samples harvested at 180 days. Statistical analysis consisted of a 2-way ANOVA for sex and diet with repeated measures for bone mineral content (BMC) and blood parameters, a 2-way ANOVA for one time measurements at 180 d including BMD of the whole body, radii, femora and lumbar vertebrae, and 1-way ANOVA to compare histomorphometric measurements.

Percent increase from baseline for BMD of the whole body was 1.8x greater in the CD group than the MA group. BMC of the whole body and lumbar vertebrae was significantly less in the MA group. Lumbar BMD on day 180 was 30% less in the MA group. Cortical bone was less affected. Radii and femora BMD was 18% and 21% less, respectively, in the MA group than in the CD group. MA treatment significantly decreased pH, HCT, iCa, HCO3, TCO2 and BE. However, no blood parameters were outside the normal range for this species. Histomorphometry revealed significantly decreased cortical area and thickness and increased mineral apposition rate and endosteal active surface length in the femoral cortex of the MA group compared to the CD group.

This study demonstrated a well compensated dietary induced MA that resulted in a significant decrease in bone mineral acquisition in juvenile sheep. Diets that induce MA may have a profound impact on lowering peak BMD in adolescents and therefore predispose individuals to osteoporosis later in life.



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