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Microbiology Insights

Synopsis: An open access, peer reviewed electronic journal that covers microbiology.


Indexing: 4 major databases. Pubmed indexing for NIH-funded research.

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About this journal

ISSN: 1178-6361


Aims and scope:

Microbiology Insights is a peer-reviewed, open access journal which encompasses all aspects of the study of microbiology. Studies on all aspects of both prokaryotic and eukaryotic microorganisms and viruses are welcome. Areas such as functionality, infectious disease, food-borne pathogens, drug resistance and antimicrobials, industrial applications and more are also incorporated in this journal. Microorganisms are of increasing importance today, in terms of subjects of study as a way of understanding more complex organisms and processes, as an industrial and medical tool, and also a threat. Open access online journals are more accessible and publish rapidly, allowing greater dissemination of knowledge in this crucial field.

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Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

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As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

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In Vitro Activity of Antimicrobial Agents Against Streptococcus Pyogenes Isolates from patients with Acute Tonsillopharyngitis in Dakar, Senegal

Authors: A. Gueye Ndiaye, ND.C. Sarr, K. Thiam and C.S. Boye
Publication Date: 10 Jun 2009
Microbiology Insights 2009:2 25-29

A. Gueye Ndiaye, ND.C. Sarr, K. Thiam and C.S. Boye

Bacteriology and Virology Laboratory, Dantec teaching hospital, 30 Pasteur Avenue, Po Box 3001, Dakar, Senegal.

Abstract

Streptococcus pyogenes (S. pyogenes) is the most important causative agent of tonsillopharyngitis. Beta-lactam antibiotics, particularly penicillin, are the drug of first choice and macrolides are recommended for patients who are allergic to penicillin. However, other antibiotics are also used for the treatment of streptococcal tonsillopharyngitis. In recent years, the increase in the incidence of respiratory tract pathogens that are resistant to current antibacterial agents highlights the need to monitor the evolution of the resistance of these pathogens to antibiotics. In this study, we assess the susceptibility of 98 isolates of S. pyogenes to 16 antibiotics. The pathogens were recovered from patients with acute tonsillopharyngitis in Dakar, the Senegalese capital city, who were recruited from May 2005 to August 2006. All strains were susceptible to penicillin with low Minimum Inhibitory Concentration (MIC = 0,016 mg/L). Amoxicillin had high activity (100%) showing its importance in treatment of streptococcal infections. Cephalosporins had MIC90 values ranging from 0.016 to 0.094 mg/L. Macrolides have shown high activity. All strains were resistant to tetracyclin. Other molecules such as teicoplanin, levofloxacin and chloramphenicol were also active and would represent alternatives to treatment of tonsillopharyngitis due to this pathogen. These results indicate that no significant resistance to antibiotics was found among patients with tonsillopharyngitis studied in Dakar. Limitations of this study were that the number of isolates tested was small and all isolates were collected from one hospital in Dakar. Hence, results may not be representative of the isolates found, in the wider community or other regions of Senegal. Further studies are needed in other parts of Dakar and other geographic regions of Senegal, in order to better clarify the antibiotic susceptibility profile of S. pyogenes isolates recovered from patients with tonsillopharyngitis.

Categories: Microbiology


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