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Cell Biology Insights

Synopsis: An open access, peer reviewed electronic journal that covers all aspects of microscopic and molecular cell biology.


Indexing: Indexed by OAIster.  Pubmed indexing for NIH-funded research.

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About this journal

ISSN: 1178-6272


Aims and scope:

Cell Biology Insights is a peer-reviewed, open-access online journal that encompasses all aspects of cell biology at both the microscopic and molecular levels. It includes, but is not limited to, cell properties, cellular compartments, metabolism, organelles, active and passive transportation, cell division, signalling, gene expression, motility, autophagy, function and interactions. Prokaryotic and eukaryotic cells of all types are included. Techniques, resources and technology developing in this area are also welcome.

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Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

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This journal has been awarded a SPARC Europe Seal. The Seal is an initiative of SPARC Europe (Scholarly Publishing and Academic Resources Coalition) and the Directory of Open Access Journals (DOAJ) which is awarded to journals applying a Creative Commons CC-BY copyright license and that make journal metadata accessible to DOAJ.  

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As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



 
 
 


A Salt-Threshold Required for Exacerbating Insulin Resistance in Dahl Salt-Sensitive (S) Rats

Authors: Marlene F. Shehata
Publication Date: 20 Aug 2008
Cell Biology Insights 2008:1 3-5

Marlene F. Shehata

University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y-4W7 and Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa ON K1H-8M5, Canada.

Abstract

The Dahl salt-sensitive (S) rat is a model of genetically determined salt-sensitivity and insulin resistance. In fact, insulin resistance is an inherited genetic trait that precedes and eventually co-exists with salt-sensitive hypertension in Dahl S, but not salt-resistant (R) Dahl rats. Owing to the critical role of salt in accelerating and exacerbating hypertension in Dahl S rats, researchers have investigated the role of salt in enhancing and/or sustaining insulin resistance in Dahl S rats. Conflicting data in the literature are available regarding the role of salt in insulin resistance in Dahl S rats. Therefore, this commentary is meant to address in depth some of the possible and relevant interpretations to some of the major findings published in the field of dietary salt contribution to insulin resistance. A conclusion has been drawn to provide a possible salt-threshold that is required for exacerbating insulin resistance in Dahl S rats.



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