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The Use of Ion Chromatography for the Determination of Clean-In-Place-200 (CIP-200) Detergent Traces

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Publication Date: 27 Feb 2007

Journal: Analytical Chemistry Insights

Citation: Analytical Chemistry Insights 2006:1 5-12

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Wilfredo Resto1, Joan Roque1, Rosamil Rey2,3, Héctor Colón2, and José Zayas2

1Department of Chemistry University of Puerto Rico-Cayey, Antonio R. Barceló Ave. Cayey P.R. 00736; 2Research and Development Division, ZAYCOR Industries Corporation, 828 de Diego Ave. Caparra Terrace, San Juan PR 00921; 3Interamerican University, Bayamón Campus, Department of Natural Sciences, Bayamon, Puerto Rico 00957.

Abstract: Anion chromatography with conductivity detection was chosen as the analytical technique for the development of a cleaning validation method for clean-in-place (CIP) detergents. The method was developed and validated for the determination of traces of the detergent CIP-200. It was shown to be linear with a squared correlation coefficient (r2) of 0.9999 and the accuracy experiments presented average recoveries of 88.2% (area response factor) from stainless steel surfaces. The repeatability was found to be 1.6% and an intermediate precision of 1.9% across the range. The method was also shown to be sensitive with an average Detection Limit (DL) of 0.23 ppm and a Quantitation Limit (QL) of 0.70 ppm based on the amount of phosphate in the detergent sample. The phosphate signal was well resolved from typical ions encountered in water samples or any other interference presented from swabs and surfaces. The method was applied to cleaning validation samples and proved to be suitable for rapid and reliable quality control.


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Posted by Emanuel Ramos Santos - 04:25,December 13, 2008

The ion chromatography has been used for the cleaning validation of CIP-100 detergent or any other detergent as Alconox, among others? Emanuel Ramos Santos graduated from UPR-Cayey Campus


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