Abstract Wei Zhang¹, Mark J. Ratain^1,2,3 and M. Eileen Dolan^1,2,3

¹Section of Hematology/Oncology, Department of Medicine, ²Committee on Clinical Pharmacology and Pharmacogenomics, ³Cancer Research Center, The University of Chicago, Chicago, IL 60637, U.S.A.

Abstract

The exploration of quantitative variation in complex traits such as gene expression and drug response in human populations has become one of the major priorities for medical genetics. The International HapMap Project provides a key resource of genotypic data on human lymphoblastoid cell lines derived from four major world populations of European, African, Chinese and Japanese ancestry for researchers to associate with various phenotypic data to find genes affecting health, disease and response to drugs. Recent progress in dissecting genetic contribution to natural variation in gene expression within and among human populations and variation in drug response are two examples in which researchers have utilized the HapMap resource. The HapMap Project provides new insights into the human genome and has applicability to pharmacogenomics studies leading to personalized medicine.

Author interview

Read an interview with Dr Wei Zhang here.

Discussion

share on

 CONNOTEA  CITEULIKE FACEBOOK LINKED IN