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Drug Target Insights

Synopsis: An open access, peer reviewed electronic journal that covers drug treatment targets.


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About this journal

ISSN: 1177-3928



Aims and scope:

Drug Target Insights covers current developments in all areas of the field of clinical therapeutics. The journal has two specific areas of focus:

  • On molecular drug targets, including disease-specific proteins, receptors, enzymes, and genes.
  • The journal seeks to elucidate the impact of new therapeutic agents on patient acceptability, preference, satisfaction and quality of life.

Drug Target Insights seeks to be the most up-to-date journal for those who need to be informed of the latest and most important developments in the field. The journal seeks to be the most reliable and up-to-date journal in this field by offering rapid and credible pre-production submission processing to authors. By publishing in open-access format, authors are able to communicate with the widest possible group of readers.

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Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

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Polymeric Nanoparticles, Nanospheres and Nanocapsules, for Cutaneous Applications

Authors: Sílvia S. Guterres, Marta P. Alves and Adriana R. Pohlmann
Publication Date: 11 Jul 2007
Drug Target Insights 2007:2 147-157

Sílvia S. Guterres1, Marta P. Alves1 and Adriana R. Pohlmann2

1Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, RS, Brazil. 2Departamento de Química Orgânica, Instituto de Química, UFRGS, Porto Alegre, RS, Brazil.

Abstract: This review presents an overview about pharmaceutical and cosmetic topical products containing polymeric nanoparticles (nanospheres and nanocapsules), reporting the main preparation and characterization methods and the studies of penetration and transport of substances through the skin. The penetration and transport extent of those systems through the skin depends on the ingredients chemical composition, on the encapsulation mechanism influencing the drug release, on the size of nanoparticles and on the viscosity of the formulations. The polymeric nanoparticles are able to modify the activity of drugs, delay and control the drug release, and increase the drug adhesivity or its time of permanence in the skin. Briefly, the nanoparticles can be useful as reservoirs of lipophilic drugs to deliver them in the stratum corneum becoming an important strategy to control their permeation into the skin.

Categories: Pharmacology


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