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Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine

Synopsis: An open access, peer reviewed electronic journal that covers circulatory, respiratory and pulmonary medicine.


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About this journal

ISSN: 1178-1157



Aims and scope:

Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine is an international, open access, peer reviewed journal which considers manuscripts on all aspects of circulatory, respiratory or pulmonary medicine. The journal welcomes articles on all aspects of the prevention, diagnosis and management of all associated disorders in addition to related genetic, pathophysiological and epidemiological topics.

The following topics are of specific, but not exhaustive, interest:

  • Lung diseases, including asthma, chronic obstructive pulmonary disease, cystic fibrosis, infectious diseases, interstitial lung diseases and lung tumors
  • Genetics
  • Lung development
  • Occupational and environmental factors
  • Pulmonary circulation
  • Pulmonary pharmacology and therapeutics
  • Respiratory critical care
  • Respiratory immunology
  • Respiratory physiology
  • Sleep
  • Circulation

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Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

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Gene Variant of the Bradykinin B2 Receptor Influences Pulmonary Arterial Pressures in Heart Failure Patients

Authors: Thomas P. Olson, Robert P. Frantz, Stephen T. Turner, Kent R. Bailey, Christina M. Wood and Bruce D. Johnson
Publication Date: 17 Feb 2009
Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine 2009:3 9-17

Thomas P. Olson1, Robert P. Frantz1, Stephen T. Turner1, Kent R. Bailey2, Christina M. Wood2 and Bruce D. Johnson1

1Departments of Internal Medicine and 2Biostatistics, Mayo Clinic, Rochester, MN, 55905.

Abstract

Background:  Pulmonary arterial pressure (PAP) varies considerably in heart failure (HF) despite similar degrees of left ventricular (LV) dysfunction. Bradykinin alters vascular tone and common variations in the kinin B2 receptor (BDKRB2) gene exists. We hypothesized that genetic variation in this receptor would influence PAP in HF.

Methods:  131 HF patients ( >1yr history systolic HF), without COPD, not currently smoking, BMI < 40, without atrial fibrillation completed the study which included a blood draw for genotyping and neurohormones (ACE, A-II, Bradykinin, ANP, BNP, and catecholamines), an echocardiogram for cardiac function and systolic PAP (PAPsys).

Results:  Mean LVEF was 29% ± 12%, NYHA class 2 ± 1, age 56 ± 12 yr, BMI 28 ± 5 kg/m2. Forty-six patients (35%) were homozygous for the +9 allele, 58 (44%) were heterozygous (+9/−9) and 27 (21%) were homozygous for the −9 allele of the BDKRB2. PAPsys averaged 42 ± 13, 38 ± 12, and 35 ± 11 mmHg for +9/+9, +9/−9 and −9/−9, respectively (p = 0.03). There was a trend towards gene effect for plasma ACE with the highest values in +9/+9 and lowest in −9/−9 patients (9.5 ± 10.7, 7.1 ± 8.7, and 5.4 ± 6.4 U/L, respectively, p = 0.06). There were no differences in plasma bradykinin or A-II, LVEF, or NYHA across genotypes.

Conclusion:  These data suggest the +9/+9 polymorphism of the BDKRB2 receptor influences pulmonary vascular tone in stable HF.



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