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Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine

Synopsis: An open access, peer reviewed electronic journal that covers circulatory, respiratory and pulmonary medicine.


Indexing: 5 major databases. Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

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About this journal

ISSN: 1178-1157


Aims and scope:

Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine is an international, open access, peer reviewed journal which considers manuscripts on all aspects of circulatory, respiratory or pulmonary medicine. The journal welcomes articles on all aspects of the prevention, diagnosis and management of all associated disorders in addition to related genetic, pathophysiological and epidemiological topics.

The following topics are of specific, but not exhaustive, interest:

  • Lung diseases, including asthma, chronic obstructive pulmonary disease, cystic fibrosis, infectious diseases, interstitial lung diseases and lung tumors
  • Genetics
  • Lung development
  • Occupational and environmental factors
  • Pulmonary circulation
  • Pulmonary pharmacology and therapeutics
  • Respiratory critical care
  • Respiratory immunology
  • Respiratory physiology
  • Sleep
  • Circulation

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

Indexing:

This journal is indexed by the following services:

  • Google Scholar
  • CAS
  • DOAJ
  • SCOPUS
  • Embase

SPARC Europe Seal award winner:

This journal has been awarded a SPARC Europe Seal. The Seal is an initiative of SPARC Europe (Scholarly Publishing and Academic Resources Coalition) and the Directory of Open Access Journals (DOAJ) which is awarded to journals applying a Creative Commons CC-BY copyright license and that make journal metadata accessible to DOAJ.  

Amongst other important services DOAJ makes metadata OAI-compliant.  This in turn enhances the visibility of papers and allows OAI-harvesters to include the details of journal articles in their services. We encourage readers to make use of this valuable resource.  The DOAJ search page is available here.

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



Editor in Chief's call for papers
 
 
 


Effect of Bronchial Thermoplasty on Airway Closure

Authors: Robert Brown, William Wizeman, Christopher Danek and Wayne Mitzner
Publication Date: 12 Oct 2007
Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine 2007:1 1-6

Robert Brown1, William Wizeman2, Christopher Danek2 and Wayne Mitzner1

1Johns Hopkins University, Baltimore, MD. 2Asthmatx, Inc., Mountain View, CA.

Abstract:

Background: Bronchial Thermoplasty, a procedure that applies thermal energy to the airway wall has been shown to impair the ability of airway to contract in response to methacholine chloride (Mch). The technique has been advocated as an alternative treatment for asthma that may permanently limit airway narrowing. In previous experimental studies in dogs and humans, it was shown that those airways treated with bronchial thermoplasty had significant impairment of Mch responsiveness.

Methods: In the present study, we investigated the ability of canine airways to close completely with very high concentrations of Mch after bronchial thermoplasty. Bronchial thermoplasty was performed on dogs using the Alair System, comprising a low power RF controller and a basket catheter with four electrodes. A local atomization of Mch agonist was delivered directly to the epithelium of the same airway locations with repeated challenges. Airway size was measured with computed tomography, and closure was considered to occur in any airway where the lumen fell below the resolution of the scanner (1 mm).

Results: Our results show that, while treated airways still have the capacity to close at very high doses of Mch, this ability is seriously impaired after treatment, requiring much higher doses.

Conclusions: Bronchial thermoplasty as currently applied seems to simply shift the entire dose response curve toward increasing airway size. Thus, this procedure simply serves to minimize the ability of airways to narrow under any level of stimulation.



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