Close
Help
Need Help?



A Comparison of Clinicopathological Features and Molecular Markers in British and Nigerian Women with Breast Cancer

Submit a Paper


Libertas Analytics


1978 Article Views

Publication Date: 24 Apr 2008

Journal: Clinical Medicine Insights: Oncology

Citation: Clinical Medicine: Oncology 2008:2 347-351

CMIonc
journal

193,117 Article Views

3,608,158 Libertas Article Views

More Statistics

Isaac D. Gukas1, Anne C. Girling2, Barnabas. M. Mandong3, Wendy Prime4, Barbara A. Jennings1 and Samuel J. Leinster1

1School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, NR47TJ, U.K. 2Department of Histopathology, Norfolk and Norwich University Hospital, Colney lane, Norwich. 3Pathology, Jos University Teaching Hospital, Jos, PMB 2076 Jos, Nigeria. 4Cancer Tissue Bank Research Centre, University of Liverpool, Liverpool, U.K.

Abstract

Background: Some studies have suggested that breast cancer in black women is more aggressive than in white women. This study’s aim was to look for evidence of differences in tumour biology between the two cohorts.

Methods: This study compared the stage, grade and pathological expression of five immunohistochemical markers (oestrogen receptor [ER], progesterone receptor [PR], ERBB2, P53 and cyclin D1 [CCND1]) in tumour biopsies from age-matched cohorts of patients from Nigeria and England. Sixty-eight suitable samples from Nigerian (n =  34) and British (n =  34) breast cancer patients were retrieved from histology tissue banks.

Results: There were significant differences between the two cohorts in the expression of ER and CCND1; and stark differences in the clinical stage at presentation. But no significant differences were observed for tumour grade.

Conclusion: There was a signifi cantly, low ER expression in the Nigerian cases which also predicts a poor response to hormonal therapy as well as a poorer prognosis. Differences in clinical stage at presentation will most likely influence prognosis between Nigerian and British women with breast cancer.


Post a Comment

x close

Discussion Add A Comment
No comments yet...Be the first to comment.


share on

Our Service Promise

  • Prompt Processing (Average 3 Weeks)
  • Fair & Constructive Peer Review
  • Professional Author Service
  • High Visibility
  • High Readership
  • What Our Authors Say

Quick Links

Follow Us We make it easy to find new research papers. RSS Feeds Email Alerts Twitter

BROWSE CATEGORIES
Our Testimonials
I found publishing in Liberas Academica a friendly process from submission, review, editing and publication.  Everything was handled to a high calibre and proficiently.  The quality of the reviews were as good as any I have experienced in publishing in scientific journals.
Professor Abdullah M Asiri (King Abdul Aziz University, Jeddah, Saudi Arabia) What our authors say