Urine Biomarkers Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) have Different Patterns in Heart Failure Exacerbation

Meyeon Park; Eric Vittinghoff; Kathleen D. Liu; Michael G. Shlipak; Chi-yuan Hsu

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Urine Biomarkers Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) have Different Patterns in Heart Failure Exacerbation

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Meyeon Park, Eric Vittinghoff, Kathleen D. Liu, Michael G. Shlipak, and Chi-yuan Hsu

Biomarker Insights 2013:8 15-18

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Published on 11 Mar 2013

DOI: 10.4137/BMI.S11479

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Abstract

Individuals with acute heart failure exacerbation often experience a deterioration in renal function. We sought to determine whether this deterioration is ischemic in nature and detectable by sensitive urine biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1). We measured serial biomarker levels and evaluated the associations of these biomarkers with renal recovery in a cohort of hospitalized patients with acute heart failure exacerbation.

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