Close
Help




JOURNAL

Japanese Clinical Medicine

Sustained Decrease of Early-Phase Insulin Secretion in Japanese Women with Gestational Diabetes Mellitus Who Developed Impaired Glucose Tolerance and Impaired Fasting Glucose Postpartum

Submit a Paper


Japanese Clinical Medicine 2015:6 35-39

Original Research

Published on 09 Dec 2015

DOI: 10.4137/JCM.S32743


Further metadata provided in PDF



Sign up for email alerts to receive notifications of new articles published in Japanese Clinical Medicine

Abstract

Objective: The aim of this study was to compare glucose intolerance in the antenatal and the postpartum periods using a 75-g oral glucose tolerance test (OGTT) in the Japanese women with gestational diabetes mellitus (GDM) using a retrospective design.

Patients and methods: Data were obtained from 85 Japanese women with GDM who delivered from April 2011 through April 2015 and who underwent an OGTT 6–14 weeks postpartum. The women were divided into two groups based on the results of the postpartum OGTT: one group with normal glucose tolerance (NGT) and the other with impaired glucose tolerance (IGT) as well as impaired fasting glucose (IFG). We analyzed the associations between postpartum IGT–IFG and various factors.

Results: Antenatally, a significant difference was observed between the groups only in the 1-hour plasma glucose level of the 75-g OGTT. Postpartum results of plasma glucose level were significantly higher at 0.5, 1, and 2 hours in the IGT–IFG group than those in the NGT group. Moreover, a significant decrease in the levels of 0.5-hour immunoreactive insulin and insulinogenic index was observed in the IGT–IFG group compared to those in the NGT group. Homeostasis model assessment-insulin resistance and homeostasis model assessment β-cell function of both groups were found to significantly decrease in the postpartum period; however, there was no significant change in the insulinogenic index of either group.

Conclusions: Our study clearly showed that the postpartum IGT and IFG levels of Japanese women with GDM are affected by impaired early-phase insulin secretion; however, insulin resistance promptly improves.



Downloads

PDF  (1.06 MB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)

XML

PMC HTML


Sharing


What Your Colleagues Say About Libertas Academica
As Editor-in-Chief of Biomarkers in Cancer I wanted to know what it is like to publish in my own journal. I have already published over 70 papers, so I knew what a range of other journals were like. I was impressed by the quality of the reviewers comments which made the paper so much better before it was accepted for publication. I was pleasantly surprised by how quickly the article went from acceptance to published, ...
Dr Barbara Guinn (University of Bedfordshire, UK)
More Testimonials

Quick Links


New article and journal news notification services
Email Alerts RSS Feeds
Facebook Google+ Twitter
Pinterest Tumblr YouTube