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Clinical Medicine: Blood Disorders

Synopsis: An open access, peer reviewed electronic journal that covers the diagnosis, management and prevention of blood disorders.


Indexing: 5 major databases. Pubmed indexing for NIH-funded research.

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About this journal

ISSN: 1178-2269


Aims and scope:

Clinical Medicine: Blood Disorders is an international, open access, peer reviewed journal which considers manuscripts on all aspects of the diagnosis, management and prevention of blood disorders, in addition to related genetic, pathophysiological and epidemiological topics.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

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National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



 
 
 


Occurrence of Acute Myeloid Leukemia in Young Pregnant Women

Authors: Juliane Menezes, Mariana Emerenciano, Flávia Pimenta, Gilson Guedes Filho, Isis Q. Magalhães, Mariana Sant’Ana, Marina Lipkin Vaskuez, Ilana Zalcberg Renault and Maria S. Pombo-de-Oliveira
Publication Date: 20 Jun 2008
Clinical Medicine: Blood Disorders 2008:1 27-31

Juliane Menezes1, Mariana Emerenciano1, Flávia Pimenta2, Gilson Guedes Filho5, Isis Q. Magalhães3, Mariana Sant’Ana1, Marina Lipkin Vasquez4, Ilana Zalcberg Renault4 and Maria S. Pombo-de-Oliveira1

1Programa de Hematologia e Oncologia Pediátricos, Centro de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil. 2Departamento Medicina Interna, Disciplina Hematologia UFPB, João Pessoa, PB, Brazil. 3Departamento de Hematologia / Oncologia Pediátrica SES-DF, Brasília, DF, Brazil. 4Centro de Transplante de Medula Óssea—CEMO—Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil. 5Departamento de Hematologia Hospital Universitário, João Pessoa, PB, Brazil.

Abstract

Although acute leukaemia is rare in pregnancy its importance lies in its life-threatening potential, both to the child and the mother. The possibility of vertical transmission of leukemic cells increases the attention devoted to these patients and their offspring. Three cases of pregnant young women (15–17 years of age) with AML are presented. This series of cases is the first report where gene abnormalities such as ITD mutations of the FLT3 gene and AML1/ETO fusion genes were screened in pregnant AML patients and their babies, so far. Unfortunately, very poor outcomes have been associated to similar cases described in literature, and the same was true to the patients described herein. Although very speculative, we think that the timing and possible similar exposures would be involved in all cases.



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Posted by
Sima Ferman
03:09,September 14, 2008

This is a very interesting report. String is the coincidence of these unusual cases in the same region and in very short time of onset of disease among cases. Because there are a lot of speculations about AML among latinos, I wonder whether the authors should persue an exploratoire epidemiological study about AML in young Brazilians.


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