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Posted Mon, Jul, 08,2013
Published today in Journal of Central Nervous System Disease is a new original research article by Mitra Assadi, Dah-Jyuu Wang, Yadira Velazquez-Rodriquez and Paola Leone. Read more about this paper below:
Title
Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy
Abstract
Metachromatic leukodystrophy (MLD) is characterized by the accumulation of sulfatide sphingolipids in the brain and peripheral nerves. We report metabolite alterations recorded using multi-voxel proton spectroscopy of the brain in four children with MLD. The data revealed elevated myoinositol/creatine and lactate/creatine ratios as well as decreased N-acetyl aspartate/creatine ratios. We propose that elevation in myoinositol and lactate are caused by astrocytic gliosis and may be used as biomarkers for disease progression in MLD.
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