Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy

Mitra Assadi; Dah-Jyuu Wang; Yadira Velazquez-Rodriquez; Paola Leone

JOURNAL

Journal of Central Nervous System Disease

Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy

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Mitra Assadi, Dah-Jyuu Wang, Yadira Velazquez-Rodriquez and Paola Leone

Journal of Central Nervous System Disease 2013:5 25-30

Original Research

Published on 04 Jul 2013

DOI: 10.4137/JCNSD.S11861

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Abstract

Metachromatic leukodystrophy (MLD) is characterized by the accumulation of sulfatide sphingolipids in the brain and peripheral nerves. We report metabolite alterations recorded using multi-voxel proton spectroscopy of the brain in four children with MLD. The data revealed elevated myoinositol/creatine and lactate/creatine ratios as well as decreased N-acetyl aspartate/creatine ratios. We propose that elevation in myoinositol and lactate are caused by astrocytic gliosis and may be used as biomarkers for disease progression in MLD.

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