Posted Fri, May, 24,2013
Published today in Evolutionary Bioinformatics is a new original research article by Chen Xu, Jing Dong, Chunfa Tong, Xindong Gong, Qiang Wen and Qiang Zhuge. Read more about this paper below:
Title
Analysis of Synonymous Codon Usage Patterns in Seven Different Citrus Species
Abstract
We used large samples of expressed sequence tags to characterize the patterns of codon usage bias (CUB) in seven different Citrus species and to analyze their evolutionary effect on selection and base composition. We found that A- and T-ending codons are predominant in Citrus species. Next, we identified 21 codons for 18 different amino acids that were considered preferred codons in all seven species. We then performed correspondence analysis and constructed plots for the effective number of codons (ENCs) to analyze synonymous codon usage. Multiple regression analysis showed that gene expression in each species had a constant influence on the frequency of optional codons (FOP). Base composition differences between the proportions were large. Finally, positive selection was detected during the evolutionary process of the different Citrus species. Overall, our results suggest that codon usages were the result of positive selection. Codon usage variation among Citrus genes is influenced by translational selection, mutational bias, and gene length. CUB is strongly affected by selection pressure at the translational level, and gene length plays only a minor role. One possible explanation for this is that the selection-mediated codon bias is consistently strong in Citrus, which is one of the most widely cultivated fruit trees.
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Interview with Professor Jamie DaviesI am definitely impressed by the manner with which Libertas Academica handled the publication of our research paper. The prompt reviews and other processes involved is a credit to the competence and experience of staff of Libertas Academica. Most outstanding is the friendly communications from the staff which kept us informed all the way through, providing guidance on our submission as it passed through a most rigorous peer review. I would recommend Libertas ...
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