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Cancer Growth and Metastasis

Enhancing Cancer Drug Discovery through Novel Cell Signaling Pathway Panel Strategy

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Cancer Growth and Metastasis 2013:6 53-59

Perspective

Published on 20 Aug 2013

DOI: 10.4137/CGM.S11134


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Abstract

The link between signaling pathways and diseases suggests the importance of pathway analysis for drug discovery. This includes target identification and validation, compound mode of action and drug candidate optimization. Here, we propose to apply cell signaling pathway panel approaches for oncology drug discovery. The strategies and guiding principles of the pathway panel approach are discussed. 2 pathway analysis examples with related processes and technology platforms are illustrated to identify cancer drugs that target cancer growth and metastasis. Finally, we highlight potential challenges and opportunities presented by the pathway panel approach.



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