Breast Cancer: Basic and Clinical Research 2015:9 81-86
Published on 23 Sep 2015
Sign up for email alerts to receive notifications of new articles published in Breast Cancer: Basic and Clinical Research
Background: Activated leukocyte cell adhesion molecules (ALCAMs) play an essential role in tumor metastasis and are higher in some patients with breast cancer.
Aim: This study aimed to evaluate ALCAM as an early diagnostic biomarker for breast cancer and how it compares with other markers.
Subjects and Methods: One-hundred and sixty-one women were selected for this study. They were divided into three groups: Group 1 consisted of 42 healthy individuals (control) while a patients groups divided into two groups according to tumour grade, Group II, Include 58 breast cancer patient’s grade II and Group III, Include 61 patients with grade III of breast cancer. Tumour markers CEA, CA 15-3 and s ALCAM levels were determined and Group 2 consisted of breast cancer patients.
Results: A highly significant elevation was recorded in s ALCAM, CA 15-3 and CEA. Percent change for grade II and grade III were [sALCAM (90, 127)], [CA15-3 (40, 72)] and [CEA (33, 156)]. Operating characteristic (ROC) curves were used to evaluate the diagnostic performance of the biomarkers ALCAM, CA15-3 and CEA with area under the curve (AUC) of (0.99 & 1.0) (AUC 0.947 & 0.99) and (AUC 0.88 & 0.94) for grade II and grade III respectively the incremental values of AUC were statistically highly significant (p < 0.001).
Conclusion: It could be concluded that serum ALCAM concentration represents a suitable biomarker for Saudi arabian breast carcinoma with high sensitivity and has the potential to be used as a diagnostic tool comparable to CA15-3 and CEA.
PDF (1.17 MB PDF FORMAT)
RIS citation (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)
BibTex citation (BIBDESK, LATEX)
I had a great experience publishing our paper in Breast Cancer: Basic and Clinical Research. The editorial team is very friendly and helpful. I was updated frequently during the entire review and publishing process. The review process is very reasonable and fair. The editor in charge has good judgement on review comments. I would recommend this journal to any researchers who conduct breast cancer research.
Facebook Google+ Twitter
Pinterest Tumblr YouTube