Close
Help




JOURNAL

Ophthalmology and Eye Diseases

The Induction of Circulating, ACAID-Inducing Monocytes Requires CCR2/CCL2-Dependent Migration of Circulating F4/80+ Cells into the Anterior Chamber

Submit a Paper


Ophthalmology and Eye Diseases 2010:257-68

Original Research

Published on 11 Nov 2010

DOI: 10.4137/OED.S6113


Further metadata provided in PDF



Sign up for email alerts to receive notifications of new articles published in Ophthalmology and Eye Diseases

Abstract

To determine the origin of peripheral blood mononulclear cells (PBMC) that activate regulatory T cells in anterior chamber-associated immune deviation (ACAID), fluorescein-labeled PBMC were intravenously injected into mice before the mice received an intracameral injection of antigen. Six-24 hr after intracameral injection, fluorescein-labeled PBMC increased in the iris. Twenty-four-48 hr labeled cells decreased in the iris and increased in the thymus and spleen. The entry of the labeled PBMC into the anterior chamber and subsequent production of PBMC that transfer ACAID required the expression of CCR2 by the PBMC and the production of the chemokine CCL2 by the recipient of the PBMC. The results suggest that the intracameral injection of antigen induces i) the infiltration of F4/80+ PBMC into the AC, ii) where these PBMC are converted to a regulatory phenotype, and iii) recirculate to activate T cells that suppress cell mediated immunity.



Downloads

PDF  (2.94 MB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)

XML

PMC HTML


Sharing


What Your Colleagues Say About Ophthalmology and Eye Diseases
I find Ophthalmology and Eye Diseases very author-friendly. As a first time author publishing in this journal I experienced close attention to authors, prompt and close co-operation in all phases of production of my manuscript encouraging. Your excellent staff simplified a daunting process that often makes authors just give up on publication due to unwarranted and irrational complexities, with close guidance to produce high quality work.
Dr Michael Okosa (Consultant Ophthalmologist and Head, Department of Ophthalmology, Nnamdi Azikiwe University Teaching Hospital and Head Guinness Eye Centre, Onitsha, Nigeria)
More Testimonials

Quick Links


New article and journal news notification services
Email Alerts RSS Feeds
Facebook Google+ Twitter
Pinterest Tumblr YouTube