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Clinical Medicine Insights: Oncology

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The Evolving Role of Maintenance Therapy Using Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR TKIs) in the Management of Advanced Non-Small-Cell Lung Cancer

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Publication Date: 12 Mar 2012

Type: Review

Journal: Clinical Medicine Insights: Oncology

Citation: Clinical Medicine Insights: Oncology 2012:6 137-147

doi: 10.4137/CMO.S5127

Abstract

The epidermal growth factor receptor (EGFR) plays an important role in the development of many cancers, including non-small cell lung cancer. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are a class of novel biologically-targeted agents widely used in the management of recurrent non-small cell lung cancer. Erlotinib, one of the EGFR TKIs, is currently FDA approved in second and third line therapy. However, recent studies showed that erlotinib is also effective as maintenance therapy after initial chemotherapy, improving disease free survival and possibly overall survival. Our current understanding of erlotinib's mechanism of action, with the discovery that EGFR mutation confers higher response rate, has propelled this agent into the first line setting. Advances in molecular testing and clinical research of this agent and other agents in this class will eventually change the way we utilize EGFR TKIs in the near future.


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What Your Colleagues Say About Clinical Medicine Insights: Oncology
Our experience publishing in Clinical Medicine Insights: Oncology was the easiest and most user-friendly interface we have encountered.  The staff were very attentive to us and kept us posted at every step of the process.  It was rewarding to have our article appear in press within weeks, compared to months at other journals.
Dr Darrell Ellsworth (Windber Research Institute, Windber, PA, USA)
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