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Cell Communication Insights

Synopsis: An open access, peer reviewed electronic journal that covers cell communication and signal transduction.


Indexing: Indexed by OAIster.  Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

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About this journal

 



Aims and scope:

Cell Communication Insights is an open access, peer reviewed journal which covers all aspects of cell communication and signal transduction. The journal aims to allow authors to rapidly publish novel findings on molecular, biochemical, immunological and diagnostic aspects of signal transduction mechanisms both intra- and intercellular in nature. This includes divers topics such as functional analysis, ligand-receptor interactions, specificity, and dysfunction.

The journal seeks to focus primarily on the work of scientists who are in the process of establishing their own labs. Submissions from senior scientists are also welcome, and it is hoped that the journal becomes a vibrant forum for the interchange of ideas between senior and junior scientists.

Indexing:

This journal is indexed by:

  • OAIster

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



 
 
 


The Evolution of Cell Communication: The Road not Taken

Authors: J.S. Torday and V.K. Rehan
Publication Date: 09 Sep 2009
Cell Communication Insights 2009:2 17-25

J.S. Torday and V.K. Rehan

Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.

Abstract

In the post-genomic era the complex problem of evolutionary biology can be tackled from the top-down, the bottom-up, or from the middle-out. Given the emergent and contingent nature of this process, we have chosen to take the latter approach, both as a mechanistic link to developmental biology and as a rational means of identifying signaling mechanisms based on their functional genomic significance. Using this approach, we have been able to configure a working model for lung evolution by reverse-engineering lung surfactant from the mammalian lung to the swim bladder of fish. Based on this archetypal cell-molecular model, we have reduced evolutionary biology to cell communication, starting with unicellular organisms communicating with the environment, followed by cell-cell communication to generate metazoa, culminating in the communication of genetic information between generations, i.e. reproduction. This model predicts the evolution of physiologic systems-including development, homeostasis, disease, regeneration/ repair, and aging- as a logical consequence of biology reducing entropy. This approach provides a novel and robust way of formulating refutable, testable hypotheses to determine the ultimate origins and first principles of physiology, providing candidate genes for phenotypes hypothesized to have mediated evolutionary changes in structure and/or function. Ultimately, it will form the basis for predictive medicine and molecular bioethics, rather than merely showing associations between genes and pathology, which is an unequivocal Just So Story. In this new age of genomics, our reach must exceed our grasp.



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