T Cell Transcription Factors and Their Impact on HIV Expression

Katarzyna Kaczmarek; Ayana Morales; Andrew J. Henderson

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Virology: Research and Treatment

T Cell Transcription Factors and Their Impact on HIV Expression

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Katarzyna Kaczmarek, Ayana Morales and Andrew J. Henderson

Virology: Research and Treatment 2013:4 41-47

Review

Published on 24 Sep 2013

DOI: 10.4137/VRT.S12147

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Abstract

By targeting CD4+ effector T cells, HIV has a dramatic impact on the depletion, expansion and function of the different polarized T cell subsets. The maturation of T cell lineages is in part driven by intrinsic transcription factors that potentially influence how efficiently HIV replicates. In this review, we explore whether transcription factors that are required for polarizing T cells influence HIV replication. In particular, we examine provirus transcription as well as the establishment and maintenance of HIV latency. Furthermore, it is suggested these factors may provide novel cell-specific therapeutic strategies for targeting the HIV latent reservoir.

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