Preventive Agents for Migraine: Focus on the Antiepileptic Drugs

R. Shahien; K. Beiruti

JOURNAL

Journal of Central Nervous System Disease

Preventive Agents for Migraine: Focus on the Antiepileptic Drugs

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R. Shahien and K. Beiruti

Journal of Central Nervous System Disease 2012:4 37-49

Review

Published on 26 Feb 2012

DOI: 10.4137/JCNSD.S9049

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Abstract

Migraine is among the 10 most disabling disorders worldwide. It is characterized by episodes of moderate or severe headaches with various degree of disability, resulting in a considerable health burden upon the sufferers and their family. The objective of this article is to review the use of prophylaxis with antiepileptic drugs. Particular focus is given to their mechanism of action, metabolism, pharmacokinetics, safety profile, efficacy and to provide a summary of the most relevant clinical studies and patient preference.

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