Paroxysmal Nocturnal Hemoglobinuria Presenting with a Left Intraventricular Thrombus in a Patient with Prior Thymoma and Aplastic Anemia

Yazan Migdady; Adam J. Olszewski

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Clinical Medicine Insights: Oncology

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Paroxysmal Nocturnal Hemoglobinuria Presenting with a Left Intraventricular Thrombus in a Patient with Prior Thymoma and Aplastic Anemia

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Yazan Migdady and Adam J. Olszewski

Clinical Medicine Insights: Oncology 2011:5 343-348

Case report

Published on 03 Nov 2011

DOI: 10.4137/CMO.S8442

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Abstract

We report the case of a 37-year old man presenting with a left ventricular cardiac thrombus in the setting of subclinical paroxysmal nocturnal hemoglobinura (PNH) developing two years after immunosuppressive therapy for thymoma-associated aplastic anemia. The literature regarding the interplay between autoimmunity and immunosuppression, aplastic anemia, thymoma and the emergence of PNH is reviewed.

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