Integrative Medicine Insights
Synopsis: An open access, peer reviewed electronic journal that covers integration of complementary medicine into the over-all pursuit of patient health.
Indexing: 5 major databases. Pubmed indexing for NIH-funded research.
Processing time: Decision in 2 weeks for 90% of papers.
Latest news:
No Protection against DSS-induced Colitis by Short-term Pretreatment with Seal or Fish Oils in Rats
Gülen Arslan1,6, Kari Erichsen1,4, Anne Marita Milde2, Lars Helgeland5, Tormod Bjørkkjær3,6, Livar Frøyland6 and Arnold Berstad1,4
1Institute of Medicine, 2Department of Biological and Medical Psychology, 3Department of Biomedicine, University of Bergen, and 4Department of Medicine and 5Department of Pathology, Haukeland University Hospital, and 6National Institute of Nutrition and Seafood Research (NIFES), Bergen, Norway.
Abstract
Background: Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have modulating effects in several chronic inflammatory conditions. The aim of the present study was to test whether prior short-term dietary supplementation with n-3 (fish or seal oil) or n-6 (soy oil) PUFA rich oils would protect the development of dextran sulfate sodium (DSS)-induced colitis in rats.
Methods: Forty-eight male Wistar rats were divided into 6 groups: no intervention, sham, DSS, seal oil + DSS, fi sh oil +DSS and soy oil + DSS. Following 7 days of acclimatisation, 1 mL oil (seal, fish or soy) or distilled water (sham) was administered by gavage day 8 to 14. Colitis was induced by 5% DSS in drinking water from day 15 to 21. Rats were sacrificed on day 23. Histological colitis (crypt and inflammation) scores, faecal granulocyte marker protein (GMP) and quantitative fatty acid composition in red blood cells were measured.
Results: Pretreatment with fish or seal oils did not significantly influence DSS induced inflammation. In fact, all the oils tended to exacerbate the inflammation. Soy oil increased the mean crypt score (P < 0.04), but not the inflammation score or GMP. The ratio of n-6 to n-3 fatty acids (FAs) was 11 to 1 and 10 to 1 in standard diet and in red blood cells of control rats, respectively. Following administration of DSS, the ratio fell in all treatment groups (P < 0.001). The lowest ratios were seen in the groups receiving DSS + fi sh or seal oils (around 6 to 1).
Conclusion: Short-term pretreatment with fish or seal oils did not protect against subsequent induction of colitis by DSS in this rat model. Whether the high ratio of n-6 to n-3 FAs in the standard diet concealed effects of n-3 FA supplementation should be further investigated.
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Integrative Medicine Insights
Steven Gurgevich, Editor in Chief
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