DrJagannadham is the author of Detecting the site of phosphorylation in phospho peptides without loss of phosphate group using MALDI TOF mass spectrometry which was recently published in Analytical Chemistry Insights.

The Editor in Chief of Analytical Chemistry Insights recently issued a call for papers.

Dr Jagannadham is a member of our favorite author program. Under the program authors are eligible to receive: prioritised peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite author program .

Please describe your experience with Libertas Academica

Libertas Academica is author friendly, particularly in communicating with the authors quickly on the progress of publishing process. It engages scientists nicely with their timely e-mail alerts.

I appreciate and encourage the efforts of Libertas Academica for their efforts in open access publications. I am sure that it is (open access publication) here to stay in the years to come.

What is the primary focus of your research?

I am working in proteomics, particularly on posttranslational modifications of proteins and also on the membrane proteins of a Gram-negative Antarctic bacterium. My research activities also involve studies on the outer membrane vesicles (OMV) of gram –ve bacteria. OMVs are proteo-lipids, known to transport molecules to prokaryotic and eukaryotic cells through a process of membrane fusion. Since these vesicles are reported to possess a role in transport of various molecules among cells, it is possible that the information on their structure will enable to design transporters.

What are the most exciting developments arising from current research in your area?

I am designing molecular transporters (protein, DNA, and other molecules) taking clues from the structural studies on the outer membrane vesicles of gram –ve bacteria.

Who are your main collaborators? Please describe your work with them

Besides Dr R Nagaraj, a senior scientist at the Centre for cellular and Molecular Biology, Hyderabad, my collaborators include Dr K Sankaran , Anna University, Chennai and Dr Anil K Tripathi, Department of Biotechnology, Banaras Hindu University, Varanasi, India. I am collaborating with Dr Nagaraj and Dr Sankaran on identification of posttranslational modifications of proteins. I worked on the function of carotenoids in bacteria and Dr Tripathi collaborated with me in this work. I am open to collaborations in proteomics.

How did you come to be working in your research area?

I started my service career at the facility group of CCMB. Here I was assigned the works on protein sequencing, amino acid analysis and HPLC analysis of various samples. While continuing my research in this area, I also involved myself in studies on the role of carotenoid pigments in cold tolerance of some Antarctic bacteria, sampled from the South Pole by Dr S.Shivaji, scientist, CCMB and subsequently characterized by his research team. Working on this project under his guidance I got a PhD from Jawaharlal Nehru University, New Delhi, India. Subsequently with the help of Dr R Nagaraj, a renowned protein chemist, I started working in protein chemistry.

What do you think about the development of open access publishing? What motivated you to use it?

Development of open access publishing is highly desirable and should be encouraged in the interest of science. Appropriate provisions should be incorporated wherever required in this process to protect intellectual property rights. I am thankful to Dr Tom Hill for his invitation to publish in Analytical Chemistry Insights.

A thorough discussion on IPR related issues for open access publications is desirable. In the competitive environment of scientific research, middle level researchers should get sufficient encouragement to publish open access publications. Middle level scientists are preferring to publish in well established high impact factor journals. These are two important issues I can think of on the spot.

What articles and/or books have you published recently?

• Jagannadham M V (2008) Identification of proteins from membrane preparations by a combination of MALDI TOF-TOF and LC coupled linear ion trap MS analysis of an Antarctic bacterium Pseudomonas syringae Lz4W , a strain with unsequenced genome. Electrophoresis. 29: 4341-4350

• Yadav, S.C; Jagannadham, M.V; Kundu,S and Jagannadham M.V. (2009) A kinetically stable plant subtilase with unique peptide mass fingerprints and dimerization properties.Bio Phys Chem.139:13-23

• Mala.G; Paithankar, K.R; Jagannadham M.V; Sundaram.C.S; Murthy,B.S.N and Lalji Singh. (2007) Characterization of novel DNA-binding proteins expressed in snake oocyte cDNA library. Protein Expr. Purif 53: 164-178

• Jagannadham M.V and Nagaraj. R (2005) Conformation of Gramicidin A in water: inference from analysis of hydrogen/ deuterium exchange behavior by MALDI mass spectrometry. Biopolymers. 80: 708-713

• Jagannadham M.V and Nagaraj R (2005) Detection of peptides covalently modified with multiple fatty acids by MALDI TOF mass spectrometry. J Pep Res 66: 94-100.

• Jagannadham MV (2009) Identifying the sequence and distinguishing the oxidized methionine from phenylalanine peptides by MALDI TOF/TOF mass spectrometry in an Antarctic bacterium Pseudomonas syringae. Proteomics insights.2:27-31.

Other information

• The Centre for Cellular and Mollecular Biology

• Contact Dr Jagannadham

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