Posted Wed, May, 28,2014
Published today in Genetics & Epigenetics is a new review article by Sarah Heerboth, Karolina Lapinska, Nicole Snyder, Meghan Leary, Sarah Rollinson and Sibaji Sarkar. Read more about this paper below:
Title
Use of Epigenetic Drugs in Disease: An Overview
Abstract
Epigenetic changes such as DNA methylation and histone methylation and acetylation alter gene expression at the level of transcription by upregulat-ing, downregulating, or silencing genes completely. Dysregulation of epigenetic events can be pathological, leading to cardiovascular disease, neurological disorders, metabolic disorders, and cancer development. Therefore, identifying drugs that inhibit these epigenetic changes are of great clinical interest. In this review, we summarize the epigenetic events associated with different disorders and diseases including cardiovascular, neurological, and metabolic disorders, and cancer. Knowledge of the specific epigenetic changes associated with these types of diseases facilitates the development of specific inhibitors, which can be used as epigenetic drugs. In this review, we discuss the major classes of epigenetic drugs currently in use, such as DNA methylation inhibiting drugs, bromodomain inhibitors, histone acetyl transferase inhibitors, histone deacetylase inhibitors, protein methyltransferase inhibitors, and histone methylation inhibitors and their role in reversing epigenetic changes and treating disease.
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Interview with Professor Jamie DaviesThis is the first time for me to submit a manuscript to Evolutionary Bioinformatics. It was really an impressive experience throughout the entire process. Every step of the process is discernible, punctual and accompanied by a professional and immediate email. Moreover, the peer reviewers provided fair and insightful comments, which significantly improved the manuscript. In addition, open access made sharing the article as easy as sharing a link with no subscriptions required and ...
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