Posted Fri, May, 23,2014
Published today in Glycobiology Insights is a new original research article by Hiroki Hamada, Kei Shimoda, Nobuyoshi Shimizu, Yoshiko Shimizu and Masaaki Akagi. Read more about this paper below:
Title
Synthesis of Glycosides of Resveratrol, Pterostilbene, and Piceatannol by Glucosyltransferase from Phytolacca americana Expressed in Bacillus subtilis and their Chemopreventive Activity Against Cancer, Allergic, and Alzheimer’s Diseases
Abstract
Resveratrol was glucosylated to its 3- and 4'-β-glucosides by the glucosyltransferase PaGT3 from Phytolacca americana expressed in Bacillus subtilis. PaGT3 glucosylated pterostilbene to its 4'-β-glucoside. Piceatannol was converted into its 4'-β-glucoside by PaGT3. Resveratrol 3-β-glucoside showed the inhibitory action of adhesion, migration, and invasion of KB cells. The resveratrol 3-β-glucoside would act as a chemopreventive agent against KB cells. Piceatannol 4'-β-glucoside showed the strongest inhibitory activity among the glycosides toward histamine release from rat peritoneal mast cells. The 4'-β-glucoside of piceatannol would be a potential therapeutic agent for allergic disease. Pterostilbene 4'-β-glucoside showed high phosphodiesterase (PDE) inhibitory activity. The 4'-β-glucoside of pterostilbene could be a potential chemopreventive agent for Alzheimer’s disease.
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Interview with Professor Jamie DaviesThe staff of Libertas Academica have been exceptionally easy to work with. They continually keep authors updated and are responsive to all requests. They were also very flexible to work with when I had some challenges from my end as an author. Article reviews were received very promptly and were constructive and helpful for improving the manuscript. The online submission system was easy to use and provided clear guidance on what was needed. I highly ...
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