Posted Tue, May, 20,2014
Published today in Journal of Central Nervous System Disease is a new original research article by Clara Hjalmarsson, Maria Bjerke, Björn Andersson, Kaj Blennow, Henrik Zetterberg, N. David Åberg, Bob Olsson, Carl Eckerström, Lena Bokemark and Anders Wallin. Read more about this paper below:
Title
Neuronal and Glia-Related Biomarkers in Cerebrospinal Fluid of Patients with Acute Ischemic Stroke
Abstract
Background: Cerebral ischemia promotes morphological reactions of the neurons, astrocytes, oligodendrocytes, and microglia in experimental studies. Our aim was to examine the profile of CSF (cerebrospinal fluid) biomarkers and their relation to stroke severity and degree of white matter lesions (WML).
Methods: A total of 20 patients (mean age 76 years) were included within 5–10 days after acute ischemic stroke (AIS) onset. Stroke severity was assessed using NIHSS (National Institute of Health stroke scale). The age-related white matter changes (ARWMC) scale was used to evaluate the extent of WML on CT-scans. The concentrations of specific CSF biomarkers were analyzed.
Results: Patients with AIS had significantly higher levels of NFL (neurofilament, light), T-tau, myelin basic protein (MBP), YKL-40, and glial fibrillary acidic protein (GFAP) compared with controls; T-Tau, MBP, GFAP, and YKL-40 correlated with clinical stroke severity, whereas NFL correlated with severity of WML (tested by Mann–Whitney test).
Conclusions: Several CSF biomarkers increase in AIS, and they correlate to clinical stroke severity. However, only NFL was found to be a marker of degree of WML.
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Thu 08 Oct, 2015
Published This Week (5th - 9th October)Thu 08 Oct, 2015
Biomarker Insights Paper Endorsed by Editor in ChiefWed 07 Oct, 2015
Interview with Professor Jamie DaviesI would like to thank the staff of Libertas Academica for their assistance in the publication process. From the first e-mail to the final approval, each member of the staff has been friendly, helpful, and professional. The whole process was seamless without any delays in processing of the manuscript. I look forward to working with Libertas Academica again.
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