Posted Tue, Apr, 29,2014
Published today in Signal Transduction Insights is a new review article by Nicholas Iverson, Naomi Galili, Abdullah M. Ali and Azra Raza. Read more about this paper below:
Title
Current View of miRNA with Tumor Suppressor Function, Exploring MDS and AML as Models
Abstract
Since the discovery of microRNAs (miRNAs) in 1993, their role in controlling a wide variety of complex and seminal cellular functions through control of gene expression continues to be elucidated. Studies of the past decade have shown that miRNAs are able to activate or suppress target genes that are key players in the molecular pathways found to be deregulated in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). The ability of miRNAs to act as tumor suppressor genes has been demonstrated in a number of studies in both human samples and cell lines as well as in murine models of AML and MDS. The focus of this review will be to examine the complex interaction of specific miRNAs with genes that have been implicated in MDS/AML and which may eventually become therapeutically relevant.
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Interview with Professor Jamie DaviesPublishing in Gene Regulation and Systems Biology was a very positive experience. I was impressed by the fast and uncomplicated submission process as well as the clear and professional peer review process which helped to improve the manuscript. The Libertas Academica team was very patient and helpful. I would definitely recommend the journal to other colleagues in the field!
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