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Promise and Reality of Metabolic Networks

Posted Thu, Apr, 17,2014

Published today in Bioinformatics and Biology Insights is a new commentary article by Susanna Bazzani.  Read more about this paper below:

Title

Promise and Reality in the Expanding Field of Network Interaction Analysis: Metabolic Networks

Abstract

In the last few decades, metabolic networks revealed their capabilities as powerful tools to analyze the cellular metabolism. Many research fields (eg, metabolic engineering, diagnostic medicine, pharmacology, biochemistry, biology and physiology) improved the understanding of the cell combining experimental assays and metabolic networks-based computations. This process led to the rise of the “systems biology” approach, where the theory meets experiments and where two complementary perspectives cooperate in the study of biological phenomena. Here, the reconstruction of metabolic networks is presented, along with established and new algorithms to improve the description of cellular metabolism. Then, advantages and limitations of modeling algorithms and network reconstruction are discussed.

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