Posted Wed, Apr, 16,2014
Published today in Bioinformatics and Biology Insights is a new original research article by Angélica Sabogal-Arango, George E. Barreto, David Ramírez-Sánchez, Juan González-Mendoza, Viviana Barreto, Ludis Morales and Janneth González. Read more about this paper below:
Title
Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel
Abstract
Sea anemone neurotoxins are peptides that interact with Na+ and K+ channels, resulting in specific alterations on their functions. Some of these neurotoxins (1ROO, 1BGK, 2K9E, 1BEI) are important for the treatment of about 80 autoimmune disorders because of their specificity for Kv1.3 channel. The aim of this study was to identify the common residues among these neurotoxins by computational methods, and establish whether there is a pattern useful for the future generation of a treatment for autoimmune diseases. Our results showed eight new key common residues between the studied neurotoxins interacting with a histidine ring and the selectivity filter of the receptor, thus showing a possible pattern of interaction. This knowledge may serve as an input for the design of more promising drugs for autoimmune treatments.
Click here to learn more about the article, download it and comment
Posted in: Articles Published
News Categories
Thu 08 Oct, 2015
Published This Week (5th - 9th October)Thu 08 Oct, 2015
Biomarker Insights Paper Endorsed by Editor in ChiefWed 07 Oct, 2015
Interview with Professor Jamie DaviesRecently we published a paper describing cloning of a new kinase gene, MLK4, in Genomics Insights.I was impressed by the prompt processing and speed of publication. The comments from the reviewers allowed me to improve the paper significantly. The reviews were scientifically deep and objective, which is very valuable because in many journals decisions to publish or not to publish are very unfair and subjective. I highly recommend that other researchers publish their papers in ...
Facebook Google+ Twitter
Pinterest Tumblr YouTube