Posted Mon, Apr, 14,2014
Published today in Biomarker Insights is a new original research article by Michelle G. Discacciati, Ismael DCG da Silva, Luisa L. Villa, Leandro Reis, Priscila Hayashi, Maria C. Costa, Silvia H. Rabelo-Santos and Luiz C. Zeferino. Read more about this paper below:
Title
Prognostic Value of DNA and mRNA E6/E7 of Human Papillomavirus in the Evolution of Cervical Intraepithelial Neoplasia Grade 2
Abstract
Objective: This study aimed at evaluating whether human papillomavirus (HPV) groups and E6/E7 mRNA of HPV 16, 18, 31, 33, and 45 are prognostic of cervical intraepithelial neoplasia (CIN) 2 outcome in women with a cervical smear showing a low-grade squamous intraepithelial lesion (LSIL).
Methods: This cohort study included women with biopsy-confirmed CIN 2 who were followed up for 12 months, with cervical smear and colposcopy performed every three months.
Results: Women with a negative or low-risk HPV status showed 100% CIN 2 regression. The CIN 2 regression rates at the 12-month follow-up were 69.4% for women with alpha-9 HPV versus 91.7% for other HPV species or HPV-negative status (P < 0.05). For women with HPV 16, the CIN 2 regression rate at the 12-month follow-up was 61.4% versus 89.5% for other HPV types or HPV-negative status (P < 0.05). The CIN 2 regression rate was 68.3% for women who tested positive for HPV E6/E7 mRNA versus 82.0% for the negative results, but this difference was not statistically significant.
Conclusions: The expectant management for women with biopsy-confirmed CIN 2 and previous cytological tests showing LSIL exhibited a very high rate of spontaneous regression. HPV 16 is associated with a higher CIN 2 progression rate than other HPV infections. HPV E6/E7 mRNA is not a prognostic marker of the CIN 2 clinical outcome, although this analysis cannot be considered conclusive. Given the small sample size, this study could be considered a pilot for future larger studies on the role of predictive markers of CIN 2 evolution.
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Interview with Professor Jamie DaviesI have published more than thirty research papers in internationally reputed high impact factor journals including Libertas Academica publications, Proteomics Insights and Analytical Chemistry Insights. I have no hesitation in saying that Proteomics Insights is highly efficient for its rapid and high quality review process and keeping the authors informed at each stage of the publication process. I recommend this journal for students, teachers and research workers who wish to publish their work. ...
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