Posted Mon, Apr, 07,2014
Published today in Biomarkers in Cancer is a new original research article by Mohammed Shaker, Kara M. Pascarelli, Matthew J. Plantinga, Miles A. Love, Alexander J. Lazar, Davis R. Ingram, Margaret von Mehren, Dina Lev, David Kipling and Dominique Broccoli. Read more about this paper below:
Title
Differential Expression of Cysteine Dioxygenase 1 in Complex Karyotype Liposarcomas
Abstract
Altered cysteine dioxygenase 1 (CDO1) gene expression has been observed in several cancers but has not yet been investigated in liposarcomas. The aim of this study was to evaluate CDO1 expression in a cohort of liposarcomas and to determine its association with clinicopathological features. Existing microarray data indicated variable CDO1 expression in liposarcoma subtypes. CDO1 mRNA from a larger cohort of liposarcomas was quantified by real time-PCR, and CDO1 protein expression was determined by immunohistochemistry (IHC) in more than 300 tumor specimens. Well-differentiated liposarcomas (WDLSs) had significantly higher CDO1 gene expression and protein levels than dedifferentiated liposarcomas (DDLSs) (P < 0.001). Location of the tumor was not predictive of the expression level of CDO1 mRNA in any histological subtype of liposarcoma. Recurrent tumors did not show any difference in CDO1 expression when compared to primary tumors. CDO1 expression was upregulated as human mesenchymal stem cells (hMSCs) undergo differentiation into mature adipocytes. Our results suggest that CDO1 is a marker of liposarcoma progression and adipogenic differentiation.
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Thu 08 Oct, 2015
Published This Week (5th - 9th October)Thu 08 Oct, 2015
Biomarker Insights Paper Endorsed by Editor in ChiefWed 07 Oct, 2015
Interview with Professor Jamie DaviesI serve as a peer reviewer for Libertas Academica and I would say LA is a great publisher to work with. The online review system is easy to navigate and the review process is straightforward. I am really looking forward to reviewing more manuscripts and submitting my own results as well in the future.
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