Posted Mon, Mar, 24,2014
Published today in Breast Cancer: Basic and Clinical Research is a new short report by Adisorn Ratanaphan and Bhutorn Canyuk. Read more about this paper below:
Title
Host Cell Reactivation and Transcriptional Activation of Carboplatin-Modified BRCA1
Abstract
The breast cancer susceptibility gene 1 (BRCA1) has been shown to maintain genomic stability through multiple functions in the regulation of DNA damage repair and transcription. Its translated BRCT (BRCA1 C-terminal domain) acts as a strong transcriptional activator. BRCA1 damaged by carboplatin treatment may lead to a loss of such functions. To address the possibility of the BRCA1 gene as a therapeutic target for carboplatin, we investigated the functional consequences of the 3′-terminal region of human BRCA1 following in vitro platination with carboplatin. A reduction in cellular BRCA1 repair of carboplatin-treated plasmid DNA, using a host cell reactivation assay, was dependent on the platination levels on the reporter gene. The transcriptional transactivation activity of the drug-modified BRCA1, assessed using a one-hybrid GAL4 transcriptional assay, was inversely proportional to the carboplatin doses. The data emphasized the potential of the BRCA1 gene to be a target for carboplatin treatment.
Click here to learn more about the article, download it and comment
Posted in: Articles Published
News Categories
Thu 08 Oct, 2015
Published This Week (5th - 9th October)Thu 08 Oct, 2015
Biomarker Insights Paper Endorsed by Editor in ChiefWed 07 Oct, 2015
Interview with Professor Jamie DaviesPublishing in “Clinical Medicine Insights: Oncology” was one of my best experience so far in an academic context. I found the process of going through submission, review, editing, and publication to be quite easy and most importantly, fair and efficient. I congratulate the team at Libertas Academica for a very well managed journal.
Facebook Google+ Twitter
Pinterest Tumblr YouTube